血管加压素及相关肽对肝细胞中糖原磷酸化酶活性和磷脂酰肌醇代谢的影响。
The influence of vasopressin and related peptides on glycogen phosphorylase activity and phosphatidylinositol metabolism in hepatocytes.
作者信息
Kirk C J, Rodrigues L M, Hems D A
出版信息
Biochem J. 1979 Feb 15;178(2):493-6. doi: 10.1042/bj1780493.
Abstract
The relative abilities of seven vasopressin-like peptides to activate hepatic glycogen phosphorylase and stimulate phosphate incorporation into phosphatidylinositol were compared. Although the individual peptides differed in their potencies, the concentrations required to stimulate phosphatidylinositol metabolism were always greater (about 10 times) than those needed to activate phosphorylase. The molecular specificity of the hepatic vasopressin receptor and the role of vasopressin-stimulated phosphatidylinositol turnover are discussed.
摘要
比较了七种血管加压素样肽激活肝糖原磷酸化酶和刺激磷酸盐掺入磷脂酰肌醇的相对能力。尽管各个肽的效力不同，但刺激磷脂酰肌醇代谢所需的浓度总是比激活磷酸化酶所需的浓度更高（约10倍）。讨论了肝血管加压素受体的分子特异性以及血管加压素刺激的磷脂酰肌醇周转的作用。
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