染色体分离机制
Chromosome segregation mechanisms.
作者信息
Nicklas R B
出版信息
Genetics. 1974 Sep;78(1):205-13. doi: 10.1093/genetics/78.1.205.
Abstract
Most aspects of chromosome distribution to the daughter cells in meiosis and mitosis are now understood, at the cellular level. The most striking evidence that the proposed explanation is valid is that it correctly predicts the outcome of experiments on living cells in which the experimenter (1) can determine the distribution of any chosen chromosome to a chosen daughter cell, (2) can induce a mal-orientation, and (3) can stabilize a mal-orientation, causing non-disjunction of a chosen bivalent. Recent reviews of chromosome distribution mechanisms are also considered, in an attempt to clarify the remaining unsolved problems.
摘要
在细胞水平上，现在已经了解了减数分裂和有丝分裂中染色体向子细胞分配的大多数方面。所提出的解释是有效的，最显著的证据是它正确地预测了对活细胞进行实验的结果，在这些实验中，实验者（1）可以确定任何选定染色体向选定子细胞的分配，（2）可以诱导错误定向，以及（3）可以稳定错误定向，导致选定二价体的不分离。为了阐明其余未解决的问题，还考虑了最近关于染色体分配机制的综述。
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