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糖尿病患者食管的神经病理学

Neuropathology of the oesophagus in diabetes mellitus.

作者信息

Smith B

出版信息

J Neurol Neurosurg Psychiatry. 1974 Oct;37(10):1151-4. doi: 10.1136/jnnp.37.10.1151.

DOI:10.1136/jnnp.37.10.1151
PMID:4443809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494860/
Abstract

Abnormalities of the innervation of the oesophagus have been shown in 18 out of 20 unselected diabetics without clinical dysphagia or neuropathy. The changes appear to be in the axons of the extrinsic and intrinsic parasympathetic fibres. It is probable that, as in the peripheral nerves, the major changes are in the Schwann cells, although here the affected fibres are unmyelinated.

摘要

在20例未经挑选的糖尿病患者中,有18例出现食管神经支配异常,这些患者并无临床吞咽困难或神经病变。变化似乎发生在外周和内在副交感神经纤维的轴突中。与外周神经一样,主要变化可能发生在施万细胞,尽管此处受影响的纤维是无髓鞘的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/653a56f09766/jnnpsyc00196-0069-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/93b961378a60/jnnpsyc00196-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/86c60334e923/jnnpsyc00196-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/cad861d225bb/jnnpsyc00196-0068-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/b824df71fb61/jnnpsyc00196-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/51d8057ee1a2/jnnpsyc00196-0069-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/653a56f09766/jnnpsyc00196-0069-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/93b961378a60/jnnpsyc00196-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/86c60334e923/jnnpsyc00196-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/cad861d225bb/jnnpsyc00196-0068-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/b824df71fb61/jnnpsyc00196-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/51d8057ee1a2/jnnpsyc00196-0069-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73db/494860/653a56f09766/jnnpsyc00196-0069-c.jpg

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本文引用的文献

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LATENT NEUROPATHY IN DIABETES AND ALCOHOLISM: ELECTROMYOGRAPHIC AND HISTOLOGICAL STUDY.糖尿病和酒精中毒中的潜在神经病变:肌电图和组织学研究
Neurology. 1965 Jan;15:19-38. doi: 10.1212/wnl.15.1.19.
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Diabetic diarrhoea.糖尿病性腹泻
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Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat.猫迷走神经及其至心脏、肺和腹部脏器分支的功能与组织学研究
Curr Treat Options Gastroenterol. 2017 Dec;15(4):475-489. doi: 10.1007/s11938-017-0153-z.
4
Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment.糖尿病对胃肠感觉运动功能的损害:对病理生理学和治疗的启示。
Curr Gastroenterol Rep. 2016 Feb;18(2):6. doi: 10.1007/s11894-015-0481-x.
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Diabetic gastrointestinal motility disorders and the role of enteric nervous system: current status and future directions.糖尿病性胃肠动力障碍与肠神经系统的作用:现状与未来方向
Neurogastroenterol Motil. 2014 May;26(5):611-24. doi: 10.1111/nmo.12330. Epub 2014 Mar 24.
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Cellular pathogenesis of diabetic gastroenteropathy.糖尿病性胃肠病的细胞发病机制
Minerva Gastroenterol Dietol. 2009 Sep;55(3):315-43.
7
Characterization of upper thoracic spinal neurons responding to esophageal distension in diabetic rats.糖尿病大鼠中对食管扩张产生反应的上胸段脊髓神经元的特征分析
Auton Neurosci. 2009 Jan 28;145(1-2):27-34. doi: 10.1016/j.autneu.2008.10.015. Epub 2008 Nov 22.
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Esophageal function worsens with long duration of diabetes.随着糖尿病病程延长,食管功能会恶化。
J Gastroenterol. 2008;43(5):338-44. doi: 10.1007/s00535-008-2169-6. Epub 2008 Jul 1.
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Morphologic and biomechanical changes of rat oesophagus in experimental diabetes.实验性糖尿病大鼠食管的形态学和生物力学变化
World J Gastroenterol. 2004 Sep 1;10(17):2519-23. doi: 10.3748/wjg.v10.i17.2519.
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Dig Dis Sci. 1999 Jan;44(1):50-5. doi: 10.1023/a:1026693815029.
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J Anat. 1954 Jul;88(3):320-37.
5
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Gut. 1967 Jun;8(3):308-12. doi: 10.1136/gut.8.3.308.
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