病例对照研究：软组织肉瘤与苯氧乙酸或氯酚暴露
Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols.
作者信息
Hardell L, Sandström A
出版信息
Br J Cancer. 1979 Jun;39(6):711-7. doi: 10.1038/bjc.1979.125.
Abstract
In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenols gave an approximately 6-fold increase in the risk for this type of tumour. It was not possible to determine, however, whether the carcinogenic effect was exerted by these compounds or by impurities such as chlorinated dibenzodioxins and dibenzofurans that in almost all cases were part of the commercial preparations.
摘要
1977年，有文献描述了一些患有软组织肉瘤且曾接触过苯氧乙酸的患者。基于这些观察结果，开展了一项匹配病例对照研究。该研究还纳入了对氯酚的暴露情况。结果显示，接触苯氧乙酸或对氯酚会使这类肿瘤的发病风险增加约6倍。然而，无法确定致癌作用是由这些化合物还是由诸如氯代二苯并二恶英和二苯并呋喃等杂质所致，而在几乎所有情况下，这些杂质都是商业制剂的一部分。
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