Hardell L, Eriksson M
Department of Oncology, University Hospital, Umea, Sweden.
Cancer. 1988 Aug 1;62(3):652-6. doi: 10.1002/1097-0142(19880801)62:3<652::aid-cncr2820620334>3.0.co;2-4.
A case-referent study on soft tissue sarcomas (STS) was conducted, to see if previous findings regarding an association between exposure to phenoxyacetic acids or chlorophenols and this tumor type could be reproduced. Fifty-five male STS patients were thereby compared with 220 living and 110 dead population-based referents. Furthermore, another referent group consisting of 190 patients with another type of malignant disease was used in order to evaluate any influence of recall bias on the results. To obtain information about exposure to the studied chemicals, as well as about any other exposures that might be of interest, questionnaires were used, and if necessary these were completed over the phone by an interviewer who had no information regarding case-referent status. All analysis and interpretation of exposure data were done in a blinded manner. Exposure to phenoxyacetic acids gave a roughly three-fold increased risk for STS, thereby confirming previous findings, whereas exposure to chlorophenols was not associated with STS in this study.
开展了一项关于软组织肉瘤（STS）的病例对照研究，以了解先前有关接触苯氧基乙酸或氯酚与这种肿瘤类型之间关联的研究结果是否能够重现。研究人员将55名男性STS患者与220名在世的以及110名已故的基于人群的对照者进行了比较。此外，还使用了由190名患有其他类型恶性疾病的患者组成的另一对照组，以评估回忆偏倚对结果的任何影响。为了获取有关接触所研究化学物质以及任何其他可能感兴趣的暴露情况的信息，研究人员使用了问卷，如有必要，由对病例对照状态一无所知的访员通过电话完成问卷。所有暴露数据的分析和解释均以盲法进行。接触苯氧基乙酸使患STS的风险大致增加了三倍，从而证实了先前的研究结果，而在本研究中，接触氯酚与STS无关。
