软组织肉瘤与化学物质暴露：一项病例对照研究。
Soft-tissue sarcomas and exposure to chemical substances: a case-referent study.
作者信息
Eriksson M, Hardell L, Berg N O, Möller T, Axelson O
出版信息
Br J Ind Med. 1981 Feb;38(1):27-33. doi: 10.1136/oem.38.1.27.
Abstract
In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a cases-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumour. A further case-referent study of soft-tissue sarcomas has now been performed to confirm these earlier findings and also to obtain further information on the effects of different phenoxy acids. This new investigation gave an increase of the same magnitude in the risk for soft-tissue sarcomas after exposure to phenoxy acids or chlorophenols, but this risk related also to exposure to phenoxy acids free from impurities, such as polychlorinated dibenzodioxins and dibenzofurans.
摘要
1977年，有几位软组织肉瘤患者被发现曾接触过苯氧基酸。这一临床观察结果促使开展了一项病例对照研究，该研究表明，接触化学性质相关的苯氧基酸或氯酚会使患此类肿瘤的风险增加约六倍。现在又进行了一项关于软组织肉瘤的病例对照研究，以证实这些早期发现，并获取有关不同苯氧基酸影响的更多信息。这项新的调查发现，接触苯氧基酸或氯酚后，患软组织肉瘤的风险增加幅度相同，但这种风险也与接触不含多氯二苯并二恶英和二苯并呋喃等杂质的苯氧基酸有关。
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