Narita M, Inui S, Yabuki Y, Namba K, Shimizu Y
Br J Exp Pathol. 1979 Apr;60(2):111-9.
Recurrent genital infection with infectious bovine rhinotracheitis (IBR) virus was induced in calves by dexamethasone (DM) treatment 3 months after primary infection. The virus was first recovered from vaginal secretions on the 3rd day after the initiation of DM treatment; however, the virus was not recovered at all from nasal secretions or from the cerebrospinal fluid of the DM-treated calves. The significant neural changes in all recurrent infected calves were nonsuppurative poliomyelitis in the lumbosacral spinal cords and their ganglia, and they were more severe in the sacrospinal cords than in other parts of the spinal cord. The virus antigen was detected in the sacrospinal ganglia and peripheral nerve fibres in the submucosa of the vagina by the fluorescent antibody technique on the 4th and 6th days after the start of DM treatment. These observations indicated that nonsuppurative poliomyelitis may be a characteristic lesion in recurrent genital infection of IBR virus. The sacrospinal cords and ganglia are considered as latent sites of IBR virus.
在初次感染3个月后，用地塞米松（DM）处理犊牛，诱导其发生传染性牛鼻气管炎（IBR）病毒的复发性生殖道感染。在开始DM处理后的第3天，首次从阴道分泌物中分离到病毒；然而，在接受DM处理的犊牛的鼻分泌物或脑脊液中根本未分离到病毒。所有复发性感染犊牛的显著神经变化是腰骶脊髓及其神经节的非化脓性脊髓灰质炎，骶脊髓中的病变比脊髓其他部位更严重。在开始DM处理后的第4天和第6天，通过荧光抗体技术在骶脊髓神经节和阴道黏膜下层的外周神经纤维中检测到病毒抗原。这些观察结果表明，非化脓性脊髓灰质炎可能是IBR病毒复发性生殖道感染的特征性病变。骶脊髓和神经节被认为是IBR病毒的潜伏部位。
