Ganote C E, Peterson D R, Carone F A
Am J Pathol. 1974 Nov;77(2):269-82.
Renal structural changes were studied sequentially between 1 hour and 6 days in rats treated with D-serine. Extensive necrosis of proximal straight tubules was rapid in onset and was followed by complete tubular regeneration 6 days post-treatment. The apparent progression of cellular changes was initial shrinkage, followed either by swelling and loss of apical cytoplasm or immediate lysis of cytoplasmic and nuclear contents. Tubular damage left only the basement membrane as a barrier between interstitial and luminal fluids. In similarly treated rats, proteinuria and glucosuria developed at the onset of tubular necrosis and disappeared when the tubules were completely relined by epithelium suggesting that they are due to diffusion of protein and glucose from interstitium into tubular fluid across the denuded basement membranes and that epithelial cells, under normal conditions, act as a barrier to diffusion of certain substances between the interstitium and tubular fluid.
在给予D-丝氨酸治疗的大鼠中，于1小时至6天期间对肾脏结构变化进行了连续研究。近端直小管广泛坏死起病迅速，治疗后6天出现完全的肾小管再生。细胞变化的明显进程是最初的收缩，随后要么是肿胀和顶端细胞质丧失，要么是细胞质和细胞核内容物立即溶解。肾小管损伤仅留下基底膜作为间质液和管腔液之间的屏障。在接受类似治疗的大鼠中，蛋白尿和糖尿在肾小管坏死开始时出现，当肾小管完全被上皮细胞重新覆盖时消失，这表明它们是由于蛋白质和葡萄糖从间质通过裸露的基底膜扩散到肾小管液中所致，并且在正常情况下，上皮细胞对某些物质在间质和肾小管液之间的扩散起到屏障作用。
