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肿瘤集落生长于受辐照的小鼠肺部。

Tumour colony growth in the irradiated mouse lung.

作者信息

Thompson S C

出版信息

Br J Cancer. 1974 Oct;30(4):337-41. doi: 10.1038/bjc.1974.202.

DOI:10.1038/bjc.1974.202
PMID:4447776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009291/
Abstract

The effect of irradiation of recipient mouse lung on tumour colony growth after intravenous injection of C3H mammary adenocarcinoma cells or aggregates was tested in C3H male mice irradiated with 14 MeV electrons to the whole or half of the thorax. Injections were made 3 h, 48 h, 3½ months or 9½ months after irradiation.The number and size of colonies were increased in irradiated areas of the lung at 48 h and at 3½ months after doses of 2000 rad. However, 9½ months after irradiation lungs were found to be atrophied and fibrotic and enumeration of tumour colonies was found to be impossible. An increase in colony growth after 250 rad was seen only at 9½ months after irradiation.

摘要

在用14兆电子伏电子对C3H雄性小鼠的整个胸部或半侧胸部进行照射后,测试了受体小鼠肺部照射对静脉注射C3H乳腺腺癌细胞或细胞聚集体后肿瘤集落生长的影响。照射后3小时、48小时、3个半月或9个半月进行注射。在给予2000拉德剂量后,48小时和3个半月时,肺部受照射区域的集落数量和大小增加。然而,照射9个半月后,发现肺部萎缩并纤维化,无法对肿瘤集落进行计数。仅在照射9个半月后,观察到250拉德照射后集落生长增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b93d/2009291/12e311eb843f/brjcancer00331-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b93d/2009291/12e311eb843f/brjcancer00331-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b93d/2009291/12e311eb843f/brjcancer00331-0053-a.jpg

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1
Tumour colony growth in the irradiated mouse lung.肿瘤集落生长于受辐照的小鼠肺部。
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引用本文的文献

1
Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs.亚临床维生素 A 缺乏不会增加辐射或未辐射肺中肿瘤的发展。
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Radiation enhancement of metastasis: a review.辐射对转移的增强作用:综述
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Effect of age and sex on lung-colony-forming efficiency of injected mouse tumour cells.年龄和性别对注射的小鼠肿瘤细胞肺集落形成效率的影响。

本文引用的文献

1
Enhancement of pulmonary metastases by x-irradiation in rats bearing mammary cancer.X射线照射对患乳腺癌大鼠肺转移的促进作用。
Cancer. 1967 Nov;20(11):2020-5. doi: 10.1002/1097-0142(196711)20:11<2020::aid-cncr2820201131>3.0.co;2-8.
2
The effect of lung irradiation on the incidence of pulmonary metastases in mice.肺部照射对小鼠肺转移发生率的影响。
Br J Radiol. 1973 Aug;46(548):613-8. doi: 10.1259/0007-1285-46-548-613.
3
Influence of preirradiation of lung on development of artificial pulmonary metastases of fibrosarcoma in mice.
Br J Cancer. 1976 Nov;34(5):566-70. doi: 10.1038/bjc.1976.212.
4
Effect of dose fractionation on the enhancement by radiation or cyclophosphamide of artificial pulmonary metastases.剂量分割对辐射或环磷酰胺增强人工肺转移的影响。
Br J Cancer. 1978 Jun;37(6):1020-5. doi: 10.1038/bjc.1978.148.
5
Pitfalls in the use of the lung colony assay to assess T-cell function in irradiated mice.使用肺集落试验评估受辐照小鼠T细胞功能时的陷阱。
Br J Cancer. 1977 Sep;36(3):386-90. doi: 10.1038/bjc.1977.204.
6
Search for an influence of natural immunity on the lung colony assay of a syngeneic transplanted murine tumour.研究天然免疫对同基因移植小鼠肿瘤肺集落试验的影响。
Br J Cancer. 1978 Jun;37(6):1083-5. doi: 10.1038/bjc.1978.157.
肺的预先照射对小鼠纤维肉瘤人工肺转移发生发展的影响。
Cancer Res. 1973 Aug;33(8):1931-6.
4
Stimulation of clonogenic growth of tumour cells and metastases in the lungs by local x-radiation.局部X线辐射对肿瘤细胞克隆生长及肺部转移的刺激作用。
Br J Cancer. 1973 Apr;27(4):291-306. doi: 10.1038/bjc.1973.36.