Thompson S C
Br J Cancer. 1976 Nov;34(5):566-70. doi: 10.1038/bjc.1976.212.
The i.v. injection of a specified number of cells of either an Ehrlich ascites tumour (ELD) or spontaneous mouse mammary adenocarcinomas (MA) into C3H mice yielded a number of lung colonies which varied significantly with the age or sex of recipient mice. The yield was higher in mice of 71 weeks than in those of 15 weeks, except for MA cells injected into females, when the yield was higher in the younger mice. Sex did not influence very significantly the yield of colonies from ELD cells; in the case of MA cells the direction of sex differences depended on age. A difference in the effect of pre-immunization with age was not observed.
给C3H小鼠静脉注射特定数量的艾氏腹水瘤(ELD)细胞或自发性小鼠乳腺腺癌(MA)细胞后,肺部出现的集落数量因受体小鼠的年龄或性别而有显著差异。除了将MA细胞注射到雌性小鼠体内时年轻小鼠的集落产量更高外,71周龄小鼠的集落产量高于15周龄小鼠。性别对ELD细胞集落产量的影响不是非常显著;对于MA细胞,性别差异的方向取决于年龄。未观察到预先免疫效果随年龄的差异。