Lawson T A, Pound A W
Br J Exp Pathol. 1974 Dec;55(6):583-8.
The extent of liver damage in rats dosed with carbon tetrachloride (CCl) or dimethylnitrosamine (DMN), by intragastric or intraperitoneal injection, has been compared in the different lobes. The level of activity of DMN-demethylase in the lobes has also been measured as an index of the activity of the microsomal enzymes. DMN-demethylase activity was greater in the left and left median lobes than in the right and right median lobes. The extent of liver damage (disruption of the basophilic bodies and necrosis) was greater in the right than in the left lobes of animals dosed with CCl but was greater in the left lobes of animals given DMN. The route of injection made no difference. The distribution of liver damage may be explained by the distribution of microsomal enzymes.
通过胃内或腹腔注射给予大鼠四氯化碳（CCl）或二甲基亚硝胺（DMN）后，对不同肝叶的肝损伤程度进行了比较。还测定了各肝叶中二甲基亚硝胺脱甲基酶的活性水平，作为微粒体酶活性的指标。左叶和左中叶的二甲基亚硝胺脱甲基酶活性高于右叶和右中叶。给予CCl的动物，右叶的肝损伤程度（嗜碱性小体破坏和坏死）大于左叶，但给予DMN的动物左叶的肝损伤程度更大。注射途径没有差异。肝损伤的分布可能由微粒体酶的分布来解释。
