Valenta J R, DiCuollo C J, Fare L R, Pagano J F
Appl Microbiol. 1974 Dec;28(6):995-8. doi: 10.1128/am.28.6.995-998.1974.
The anthelmintic agent methyl 5(6)-butyl-2-benzimidazolecarbamate (Parbendazole) was transformed to two of its animal metabolites, methyl 5(6)-(4-hydroxybutyl)-2-benzimidazolecarbamate and methyl 5(6)-3-(carboxypropyl)-2-benzimidazolecarbamate, by the filamentous fungus Cunninghamella bainieri ATCC 9244. The transformation pathway was shown to be through the 4-hydroxybutyl product to the 3-carboxypropyl product. The reaction favored accumulation of the latter product.
抗蠕虫药5(6)-丁基-2-苯并咪唑氨基甲酸甲酯（帕苯达唑）被丝状真菌拜氏小克银汉霉ATCC 9244转化为其两种动物代谢产物，即5(6)-(4-羟基丁基)-2-苯并咪唑氨基甲酸甲酯和5(6)-3-(羧基丙基)-2-苯并咪唑氨基甲酸甲酯。转化途径显示为通过4-羟基丁基产物生成3-羧基丙基产物。该反应有利于后一种产物的积累。
