胃肠道肿瘤的细胞免疫、外周血淋巴细胞计数及病理分期
Cellular immunity, peripheral blood lymphocyte count and pathological staging of tumours in the gastrointestinal tract.
作者信息
Bone G, Lauder I
出版信息
Br J Cancer. 1974 Sep;30(3):215-21. doi: 10.1038/bjc.1974.184.
Abstract
The peripheral blood lymphocyte count has been measured in 74 cases of histologically proven carcinoma of the gastrointestinal tract. The count has been correlated with the pathological stage of tumour spread and the patient's delayed hypersensitivity response to 2.4 dinitrochlorobenzene (DNCB). A statistically significant correlation was found between the peripheral blood lymphocyte count and the response to DNCB. There was linear association between the extent of spread of the tumours and the lymphocyte count. Those patients with low peripheral blood lymphocyte counts tended to have more advanced tumours and a poor response to DNCB. The possible causes of this lymphopenia are discussed.
摘要
对74例经组织学证实的胃肠道癌患者进行了外周血淋巴细胞计数。该计数与肿瘤扩散的病理分期以及患者对2,4-二硝基氯苯（DNCB）的迟发型超敏反应相关。在外周血淋巴细胞计数与对DNCB的反应之间发现了具有统计学意义的相关性。肿瘤扩散程度与淋巴细胞计数之间存在线性关联。外周血淋巴细胞计数低的患者往往肿瘤进展更严重，且对DNCB反应较差。本文讨论了这种淋巴细胞减少的可能原因。
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