大麻、儿茶酚胺、快速眼动睡眠与攻击行为

Cannabis, catecholamines, rapid eye movement sleep and aggressive behaviour.

作者信息

Carlini E A, Lindsey C J, Tufik S

出版信息

Br J Pharmacol. 1977 Nov;61(3):371-9. doi: 10.1111/j.1476-5381.1977.tb08429.x.

DOI:10.1111/j.1476-5381.1977.tb08429.x

PMID:201320

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667897/

Abstract

Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present paper describes new experiments dealing with this subject. 2. Previous REM sleep-deprivation enhanced both delta9-tetrahydrocannabinol (THC)-induced hypothermia and nomifensine effects on aggressive behaviour. 3. A marihuana extract decreased brain dopamine turnover in REM sleep-deprived rats, an effect not observed in non-deprived rats. Noradrenaline metabolism was not altered. 4. Fighting behaviour was elicited in REM sleep-deprived rats treated with 4 different dopamine-beta-hydroxylase inhibitors. 5. Apomorphine, nomifensine and delta9-THC administered to non-deprived rats pretreated with bis(4-methyl-1-homopiperanzinyl-thiocarbonyl) disulphide (Fla-63), induced fighting behaviour. 6. Nomifensine and apomorphine induced fighting in non-deprived rats pretreated with delta9-THC. 7. Clonidine inhibited the fighting elicited in REM sleep-deprived rats by either delta9-THC or Fla-63 pretreatment. 8. The data are discussed in terms of the influence of REM sleep-deprivation (or the stress associated with deprivation) on the response to dopaminergic drugs and cannabis. Taken together they emphasize the participation of brain dopamine and noradrenaline systems in the aggressive behaviour studied.

摘要

我们实验室之前的研究表明，大麻会在被剥夺快速眼动（REM）睡眠的大鼠中诱发攻击性行为。有人认为这种效应与脑儿茶酚胺有关，多巴胺起激动剂作用，去甲肾上腺素起抑制作用。本文描述了针对该主题的新实验。2. 先前的REM睡眠剥夺增强了Δ⁹-四氢大麻酚（THC）诱发的体温过低以及诺米芬辛对攻击性行为的影响。3. 大麻提取物降低了REM睡眠剥夺大鼠的脑多巴胺周转率，而在未被剥夺睡眠的大鼠中未观察到这种效应。去甲肾上腺素代谢未改变。4. 用4种不同的多巴胺-β-羟化酶抑制剂处理的REM睡眠剥夺大鼠出现了打斗行为。5. 给用双（4-甲基-1-高哌嗪基-硫代羰基）二硫化物（Fla-63）预处理的未被剥夺睡眠的大鼠注射阿扑吗啡、诺米芬辛和Δ⁹-THC，诱发了打斗行为。6. 诺米芬辛和阿扑吗啡在用Δ⁹-THC预处理的未被剥夺睡眠的大鼠中诱发了打斗行为。7. 可乐定抑制了用Δ⁹-THC或Fla-63预处理的REM睡眠剥夺大鼠所引发的打斗行为。8. 根据REM睡眠剥夺（或与剥夺相关的应激）对多巴胺能药物和大麻反应的影响对数据进行了讨论。综合来看，它们强调了脑多巴胺和去甲肾上腺素系统在所研究的攻击性行为中的参与。