关于致敏脾细胞在体外对鸡红细胞进行裂解过程中抗体参与情况的证明。
The demonstration of the involvement of antibody in the in vitro lysis of chicken erythrocytes by allergized spleen cells.
作者信息
Macphail S, Munro A J
出版信息
Immunology. 1974 Dec;27(6):1053-62.
Abstract
The experiments described demonstrate that the lysis of chicken erythrocytes (CRC) by allergized mouse spleen cells (ASC) is an antibody-dependent phenomenon. Supernatants obtained from cultures of ASC were shown to contain antibody which could effect antibody-dependent cell-mediated cytotoxicity. The cytolysis observed with ASC was inhibited by both an IgG fraction and a F(ab') portion of rabbit anti-mouse IgG. No inhibition was obtained by pretreating the ASC with AKR anti-C3Hθ serum and guinea-pig complement.
摘要
所述实验表明，致敏小鼠脾细胞（ASC）对鸡红细胞（CRC）的裂解是一种抗体依赖性现象。从ASC培养物中获得的上清液显示含有可影响抗体依赖性细胞介导的细胞毒性的抗体。用兔抗小鼠IgG的IgG组分和F(ab')部分均能抑制ASC所观察到的细胞溶解。用AKR抗C3Hθ血清和豚鼠补体预处理ASC未获得抑制作用。
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引用本文的文献
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The class of antibody involved in the antibody-dependent cell-mediated lysis of chicken erythrocytes.参与鸡红细胞抗体依赖性细胞介导裂解的抗体类别。
Immunology. 1976 Nov;31(5):697-705.
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Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes.抗体依赖性淋巴细胞介导的细胞毒性：无需胸腺衍生淋巴细胞。
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Nature. 1974 Jan 18;247(5437):148-50. doi: 10.1038/247148a0.
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