抗体依赖性细胞毒性细胞的特性。一种非吞噬性单核细胞？
Characterization of the antibody-dependent cytotoxic cell. A non-phagocytic monocyte?
作者信息
Greenberg A H, Shen L, Roitt I M
出版信息
Clin Exp Immunol. 1973 Oct;15(2):251-9.
Abstract
Death of antibody-coated chicken erythrocytes (CRBC) mediated by nonphagocytic cells was studied. The distribution of effector cells in mouse spleen lymphoid populations after fractionation by velocity sedimentation on Ficoll gradients, isopycnic centrifugation on BSA gradients, and affinity chromatography on Sephadex-linked anti-Fab columns was followed. Cytotoxicity corresponded closely with the distribution of the non-phagocytic monocytes. The cytotoxic effector cell showed similar characteristics to monocytes with respect to size, surface adherence properties and binding affinity for immunoglobulin subclasses.
摘要
研究了非吞噬细胞介导的抗体包被鸡红细胞（CRBC）的死亡。通过在Ficoll梯度上进行速度沉降、在BSA梯度上进行等密度离心以及在Sephadex连接的抗Fab柱上进行亲和层析对小鼠脾脏淋巴群体进行分级分离后，追踪效应细胞的分布。细胞毒性与非吞噬性单核细胞的分布密切相关。细胞毒性效应细胞在大小、表面黏附特性以及对免疫球蛋白亚类的结合亲和力方面表现出与单核细胞相似的特征。
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