甘油酯甘油合成途径。
Pathways of glyceride glycerol synthesis.
作者信息
Rognstad R, Clark D G, Katz J
出版信息
Biochem J. 1974 May;140(2):249-51. doi: 10.1042/bj1400249.
Abstract
Isolated rat liver parenchymal cells were incubated for various periods with [U-(14)C,2-(3)H]glycerol and the radioisotopic yields in the major products were determined, as well as the (3)H/(14)C ratios in glyceride glycerol and intracellular glycerol phosphate. Under the conditions used (0.1mm-glycerol+10mm-l-lactate or 10mm-glycerol as substrates), only small differences were found between these (3)H/(14)C ratios. The results suggest a minor role for a pathway of glyceride glycerol synthesis involving reduction of acylated dihydroxyacetone phosphate, under these experimental conditions.
摘要
将分离的大鼠肝脏实质细胞与[U-(14)C,2-(3)H]甘油孵育不同时间，测定主要产物中的放射性同位素产率，以及甘油酯甘油和细胞内甘油磷酸中的(3)H/(14)C 比值。在所使用的条件下（以0.1mmol/L甘油+10mmol/L L-乳酸或10mmol/L甘油作为底物），这些(3)H/(14)C 比值之间仅发现微小差异。结果表明，在这些实验条件下，涉及酰化磷酸二羟丙酮还原的甘油酯甘油合成途径作用较小。
相似文献
1
Pathways of glyceride glycerol synthesis.甘油酯甘油合成途径。
Biochem J. 1974 May;140(2):249-51. doi: 10.1042/bj1400249.
2
The tritium isotope effect of sn-glycerol 3-phosphate oxidase and the effects of clofenapate and N-(2-benzoyloxyethyl)norfenfluramine on the esterification of glycerol phosphate and dihydroxyacetone phosphate by rat liver mitochondria.3-磷酸甘油氧化酶的氚同位素效应以及氯苯那酯和N-(2-苯甲酰氧基乙基)去甲氟胺对大鼠肝脏线粒体中磷酸甘油和磷酸二羟丙酮酯化作用的影响。
Biochem J. 1973 Oct;136(2):421-7. doi: 10.1042/bj1360421.
3
Isomerization of L-glyceraldehyde to dihydroxyacetone during glyceride synthesis by rat liver microsomes.大鼠肝脏微粒体在甘油酯合成过程中L-甘油醛异构化为二羟基丙酮。
Lipids. 1971 Dec;6(12):930-4. doi: 10.1007/BF02531177.
4
Production and preferential utilization of dihydroxyacetone phosphate for glyceride synthesis in the presence of glycerol 3-phosphate.在磷酸甘油存在的情况下，磷酸二羟丙酮用于甘油酯合成的生成及优先利用。
Biochem Biophys Res Commun. 1971 Sep;44(5):1279-84. doi: 10.1016/s0006-291x(71)80224-3.
5
Dietary regulation of phosphatidic acid synthesis from dihydroxyacetone phosphate and fatty acid by rat liver microsomes.大鼠肝脏微粒体对磷酸二羟丙酮和脂肪酸合成磷脂酸的膳食调节。
Lipids. 1971 Feb;6(2):88-92. doi: 10.1007/BF02531322.
6
Glyceroneogenesis and the supply of glycerol-3-phosphate for glyceride-glycerol synthesis in liver slices of fasted and diabetic rats.禁食和糖尿病大鼠肝脏切片中甘油异生作用及甘油-3-磷酸用于甘油酯甘油合成的供应情况
Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1352-7. doi: 10.1152/ajpendo.00394.2007. Epub 2007 Aug 28.
7
Alternate triose phosphate pathways for glyceride biosynthesis in rat liver.大鼠肝脏中甘油酯生物合成的交替磷酸丙糖途径。
Biochem Biophys Res Commun. 1968 Apr 19;31(2):252-6. doi: 10.1016/0006-291x(68)90738-9.
8
Measurement of flow of carbon atoms from glucose and glycogen glucose to glyceride glycerol and glycerol in rat heart and epididymal adipose tissue. Effects of insulin, adrenaline and alloxan-diabetes.大鼠心脏和附睾脂肪组织中碳原子从葡萄糖、糖原葡萄糖流向甘油三酯甘油和甘油的流量测定。胰岛素、肾上腺素和四氧嘧啶糖尿病的影响。
Biochem J. 1967 Aug;104(2):423-34. doi: 10.1042/bj1040423.
9
Triose phosphates as precursors of glyceride biosynthesis by rat liver microsomes.磷酸丙糖作为大鼠肝脏微粒体甘油酯生物合成的前体。
Lipids. 1970 Sep;5(9):770-5. doi: 10.1007/BF02531391.
10
Loss of hydrogen from dihydroxyacetone phosphate during glyceryl ether synthesis.甘油醚合成过程中磷酸二羟丙酮的氢损失。
J Biol Chem. 1971 Sep 25;246(18):5822-7.
引用本文的文献
1
Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait.甘油作为糖耐量受损的一个关联因素：利用简单遗传性状剖析复杂系统。
Am J Hum Genet. 2000 May;66(5):1558-68. doi: 10.1086/302903. Epub 2000 Mar 27.
2
Fatty acid specificities of microsomal acyltransferases esterifying positions-1 and -2 of acylglycerols in mammary glands from lactating rats.泌乳大鼠乳腺中酰基甘油1位和2位酯化的微粒体酰基转移酶的脂肪酸特异性
Biochem J. 1980 May 1;187(2):289-95. doi: 10.1042/bj1870289.
3
Heterogeneity of the sn-glycerol 3-phosphate pool in isolated hepatocytes, demonstrated by the use of deuterated glycerols and ethanol.通过使用氘代甘油和乙醇证明分离的肝细胞中3-磷酸甘油池的异质性。
Biochem J. 1984 Dec 15;224(3):731-9. doi: 10.1042/bj2240731.
4
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.用于甘油脂质生物合成的酰基二羟基丙酮磷酸途径酶存在于酿酒酵母中。
J Bacteriol. 1992 Sep;174(17):5702-10. doi: 10.1128/jb.174.17.5702-5710.1992.
5
Phosphatidic acid biosynthesis in rat liver mitochondria and microsomal fractions. Regulation of fatty acid positional specificity.大鼠肝脏线粒体和微粒体组分中磷脂酸的生物合成。脂肪酸位置特异性的调节。
Biochem J. 1976 Aug 15;158(2):249-54. doi: 10.1042/bj1580249.
6
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment.大鼠肝脏线粒体和微粒体组分中甘油磷酸酰基转移酶和磷酸二羟丙酮酰基转移酶活性的研究。在实质细胞和非实质细胞中的相对分布、N-乙基马来酰亚胺的影响、棕榈酰辅酶A浓度、饥饿、肾上腺切除术及抗胰岛素血清处理的影响
Biochem J. 1979 Sep 15;182(3):751-62. doi: 10.1042/bj1820751.
7
Proportional activities of glycerol kinase and glycerol 3-phosphate dehydrogenase in rat hepatomas.大鼠肝癌中甘油激酶和3-磷酸甘油脱氢酶的比例活性。
Biochem J. 1975 Jun;148(3):545-50. doi: 10.1042/bj1480545.
8
Glycerolipid biosynthesis in Saccharomyces cerevisiae: sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities.酿酒酵母中的甘油酯生物合成：sn-甘油-3-磷酸和磷酸二羟丙酮酰基转移酶活性
J Bacteriol. 1978 Mar;133(3):1368-76. doi: 10.1128/jb.133.3.1368-1376.1978.
本文引用的文献
1
Acyl dihydroxyacetone phosphate. A rapidly labeled lipid in guinea pig liver mitochondria.酰基二羟基丙酮磷酸酯。豚鼠肝线粒体中一种快速标记的脂质。
J Biol Chem. 1967 Mar 10;242(5):1074-5.
2
The metabolism of glucose-2-T by adipose tissue.
J Biol Chem. 1969 Jan 10;244(1):99-106.
3
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.
4
Tritium isotope effects in the measurement of the glycerol phosphate and dihydroxyacetone phosphate pathways of glycerolipid biosynthesis in rat liver.氚同位素效应在大鼠肝脏甘油磷脂生物合成中甘油磷酸和磷酸二羟丙酮途径测量中的应用
Biochem J. 1972 Dec;130(4):1003-12. doi: 10.1042/bj1301003.
5
The metabolism of tritiated glucose by rat adipose tissue.大鼠脂肪组织对氚标记葡萄糖的代谢
J Biol Chem. 1966 Aug 10;241(15):3600-10.
6
The pentose cycle, triose phosphate isomerization, and lipogenesis in rat adipose tissue.大鼠脂肪组织中的戊糖循环、磷酸丙糖异构化和脂肪生成。
J Biol Chem. 1966 Feb 10;241(3):727-40.
7
Enzymic degradation of isotopically labeded compounds. II. Glucose labeled with 14C and tritium.同位素标记化合物的酶促降解。II. 用¹⁴C和氚标记的葡萄糖。
Anal Biochem. 1970 Mar;34:170-9. doi: 10.1016/0003-2697(70)90098-9.
8
Enzymic degradation of isotopically labeled compounds. I. Degradation of 14C-labeled glycerol.
Anal Biochem. 1970 Mar;34:161-9. doi: 10.1016/0003-2697(70)90097-7.
Zotero 插件