Barnard R O, Triggs M
J Neurol Neurosurg Psychiatry. 1974 Nov;37(11):1259-64. doi: 10.1136/jnnp.37.11.1259.
A neuropathological study of 20 multiple sclerosis brains using celloidin-embedded slices was carried out to assess the extent of changes in the corpus callosum. Severe atrophy of the callosum was found in cases with marked hydrocephalus. Demyelination of the callosum varied in extent from slight involvement (with a few small plaques) to almost total myelin loss. A clinical history of mental deterioration was usual in the cases with severe callosal lesions, but no symptoms were recorded that indicated a specific disconnection syndrome. The ventricular enlargement noted in this series could not be explained either on the basis of obstruction to the flow of cerebrospinal fluid, or by the effects of shrinkage of the white matter.
对20例多发性硬化症患者的大脑进行了神经病理学研究，采用火棉胶包埋切片来评估胼胝体的病变程度。在有明显脑积水的病例中发现胼胝体严重萎缩。胼胝体的脱髓鞘程度不一，从轻度受累（有一些小斑块）到几乎完全失去髓鞘。在有严重胼胝体病变的病例中，通常有精神衰退的临床病史，但未记录到表明特定分离综合征的症状。本系列中 noted 的脑室扩大既不能用脑脊液流动受阻来解释，也不能用白质萎缩的影响来解释。 （注：原文中“ventricular enlargement noted in this series”中的“noted”翻译为“ noted ”是因为没有上下文明确其准确含义，保留英文更合适，可根据实际情况调整）
