阿米卡星（BB-K8）治疗多重耐药变形杆菌感染。
Amikacin (BB-K8) treatment of multiple-drug resistant Proteus infections.
作者信息
Sharp P M, Saenz C A, Martin R R
出版信息
Antimicrob Agents Chemother. 1974 May;5(5):435-8. doi: 10.1128/AAC.5.5.435.
Abstract
The new aminoglycoside antibiotic, amikacin (formerly called BB-K8), was used to treat 12 episodes of urinary tract infection caused by hospital-acquired Proteus rettgeri strains. These bacteria were resistant in vitro to kanamycin and gentamicin, and infection persisted in most of the patients in spite of therapy with one of these agents. In all cases, the urinary tract infection was controlled or eradicated by therapy, although relapse or reinfection was frequently encountered in these patients with complicated urological problems. No toxicities attributable to the drug were encountered in the small group of patients.
摘要
新型氨基糖苷类抗生素阿米卡星（以前称为BB-K8）用于治疗12例由医院获得性雷氏变形杆菌菌株引起的尿路感染。这些细菌在体外对卡那霉素和庆大霉素耐药，尽管使用其中一种药物进行治疗，但大多数患者的感染仍持续存在。在所有病例中，尽管这些患有复杂泌尿系统问题的患者经常出现复发或再感染，但通过治疗尿路感染得到了控制或根除。在这一小群患者中未发现该药物引起的毒性反应。
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本文引用的文献
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2
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3
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