阿米卡星的体外活性、协同作用及测试参数，并与其他氨基糖苷类抗生素进行比较。
In vitro activity, synergism, and testing parameters of amikacin, with comparisons to other aminoglycoside antibiotics.
作者信息
Kelly M T, Matsen J M
出版信息
Antimicrob Agents Chemother. 1976 Mar;9(3):440-7. doi: 10.1128/AAC.9.3.440.
Abstract
The activity of the new aminoglycoside antibiotic, amikacin, was evaluated in vitro against 219 clinical bacterial isolates. One hundred eighty-nine of the 219 strains had agar dilution minimal inhibitory concentration values of 8.0 mug/ml or less for amikacin. Comparative agar dilution studies were performed for gentamicin, kanamycin, and tobramycin. Gentamicin was the most active overall, but tobramycin and amikacin also had significant activity against most bacterial groups. The effects of divalent cations on the susceptibility of Pseudomonas aeruginosa to amikacin were evaluated, and the minimal inhibitory concentration values varied sixfold over a range of divalent cation concentrations from 0.2 to 8.75 mg%. The effects of media and inoculum size on disk susceptibility testing with amikacin were also evaluated. In addition, a synergistic interaction between carbenicillin and amikacin against P. aeruginosa was demonstrated. Amikacin appears to be a promising new broad spectrum antimicrobial agent.
摘要
对新型氨基糖苷类抗生素阿米卡星的活性进行了体外评估，以检测其对219株临床分离细菌的作用。在这219株菌株中，有189株对阿米卡星的琼脂稀释最低抑菌浓度值为8.0微克/毫升或更低。对庆大霉素、卡那霉素和妥布霉素进行了比较琼脂稀释研究。总体而言，庆大霉素活性最强，但妥布霉素和阿米卡星对大多数细菌群也有显著活性。评估了二价阳离子对铜绿假单胞菌对阿米卡星敏感性的影响，在二价阳离子浓度从0.2至8.75毫克%的范围内，最低抑菌浓度值变化了6倍。还评估了培养基和接种量对阿米卡星纸片药敏试验的影响。此外，还证明了羧苄西林与阿米卡星对铜绿假单胞菌有协同作用。阿米卡星似乎是一种有前景的新型广谱抗菌剂。
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本文引用的文献
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A microdilution method for antibiotic susceptibility testing: an evaluation.一种用于抗生素敏感性测试的微量稀释法：一项评估。
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A virulent nosocomial Klebsiella with a transferable R factor for gentamicin: emergence and suppression.一种带有可转移庆大霉素R因子的致病性医院内感染克雷伯菌：出现与控制。
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Colonization with gentamicin-resistant Pseudomonas aeruginosa, pyocine type 5, in a burn unit.在一个烧伤病房中出现对庆大霉素耐药的5型绿脓杆菌定植。
J Infect Dis. 1971 Dec;124 Suppl:S18-23. doi: 10.1093/infdis/124.supplement_1.s18.
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Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus.五种氨基糖苷类抗生素对革兰氏阴性杆菌和金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1973 Dec;4(6):617-25. doi: 10.1128/AAC.4.6.617.
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In vitro studies of BB-K8, a new aminoglycoside antibiotic.新型氨基糖苷类抗生素BB-K8的体外研究
Antimicrob Agents Chemother. 1973 Aug;4(2):186-92. doi: 10.1128/AAC.4.2.186.
6
In vitro evaluation of a new aminoglycoside derivative of kanamycin, a comparison with tobramycin and gentamycin.卡那霉素一种新氨基糖苷衍生物的体外评估，与妥布霉素和庆大霉素的比较。
Antimicrob Agents Chemother. 1973 Apr;3(4):532-3. doi: 10.1128/AAC.3.4.532.
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BB-K 8, a new semisynthetic aminoglycoside antibiotic.
J Antibiot (Tokyo). 1972 Dec;25(12):695-708. doi: 10.7164/antibiotics.25.695.
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Appl Microbiol. 1969 Sep;18(3):469-73. doi: 10.1128/am.18.3.469-473.1969.
10
Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibiotics.BB-K8（阿米卡星）对耐一种或多种氨基糖苷类抗生素的临床分离株的活性。
Antimicrob Agents Chemother. 1974 Feb;5(2):143-52. doi: 10.1128/AAC.5.2.143.
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