别嘌呤醇的抗利什曼原虫作用。
Antileishmanial effect of allopurinol.
作者信息
Pfaller M A, Marr J J
出版信息
Antimicrob Agents Chemother. 1974 May;5(5):469-72. doi: 10.1128/AAC.5.5.469.
Abstract
Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) has been shown to inhibit the growth of Leishmania braziliensis in vitro at concentrations which are attainable in human tissues and body fluids. This compound is believed to act by interdicting the de novo synthesis of pyrimidines, probably through the formation of allopurinol ribotide. Its lack of toxicity makes it a potential candidate for animal experimentation and it may serve as a prototype for other agents with similar mechanisms of action.
摘要
别嘌醇（4-羟基吡唑并[3,4-d]嘧啶）已被证明在人体组织和体液可达到的浓度下能在体外抑制巴西利什曼原虫的生长。据信该化合物通过阻断嘧啶的从头合成起作用，可能是通过形成别嘌醇核糖核苷酸。其低毒性使其成为动物实验的潜在候选物，并且它可能作为具有类似作用机制的其他药物的原型。
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本文引用的文献
1
The metabolism of Leishmania donovani in culture.杜氏利什曼原虫在培养中的代谢。
Biochem J. 1954 Feb;56(2):182-5. doi: 10.1042/bj0560182.
2
Respiratory changes accompanying Leishmania to leptomonad transformation in Leishmania donovani.
Exp Parasitol. 1967 Feb;20(1):51-5. doi: 10.1016/0014-4894(67)90021-5.
3
Effects of long-chain mono- and dicarboxylic acids on the pteridine requirement of Crithidia.长链单羧酸和二羧酸对克氏锥虫蝶啶需求的影响。
Arch Biochem Biophys. 1966 Aug;115(2):401-6. doi: 10.1016/0003-9861(66)90289-x.
4
Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.黄嘌呤氧化酶抑制剂别嘌醇的代谢研究。
Biochem Pharmacol. 1966 Jul;15(7):863-80. doi: 10.1016/0006-2952(66)90163-8.
5
Pteridine requirement of the hemoflagellate Leishmania tarentolae.血液鞭毛虫塔氏利什曼原虫对蝶啶的需求。
J Protozool. 1969 May;16(2):372-5. doi: 10.1111/j.1550-7408.1969.tb02284.x.
6
6-Hydroxylation of the pteridine ring by xanthine oxidase.黄嘌呤氧化酶对蝶啶环的6-羟基化作用。
Biochem Biophys Res Commun. 1968 Jun 10;31(5):837-41. doi: 10.1016/0006-291x(68)90639-6.
7
Antagonists of growth inhibition of Crithidia by allopurinol, a guanine analog.别嘌呤醇（一种鸟嘌呤类似物）对克氏锥虫生长抑制作用的拮抗剂。
J Protozool. 1970 May;17(2):153-8. doi: 10.1111/j.1550-7408.1970.tb02346.x.
8
[Pterins as active substances and pigments].[蝶呤作为活性物质和色素]
Ergeb Physiol. 1965;56:1-66.
9
Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis.别嘌醇介导的嘧啶生物合成抑制机制。
J Lab Clin Med. 1971 Nov;78(5):696-704.
10
The leishmania-leptomonad transformation of Leishmania donovani: nutritional requirements, respiration changes and antigenic changes.
J Protozool. 1968 Feb;15(1):201-7. doi: 10.1111/j.1550-7408.1968.tb02112.x.
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