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大鼠患血紫质病期间苯丙氨酸和酪氨酸的分布与代谢

Distribution and metabolism of phenylalanine and tyrosine during tualraemia in the rat.

作者信息

Powanda M C, Dinterman R E, Wannemacher R W, Herbrandson G D

出版信息

Biochem J. 1974 Oct;144(1):173-6. doi: 10.1042/bj1440173.

DOI:10.1042/bj1440173
PMID:4462572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168479/
Abstract

Tularaemia in rats causes a doubling of the serum phenylalanine/tyrosine ratio and a more than twofold increase in muscle phenylalanine which cannot be accounted for by decreased hepatic phenylalanine hydroxylase (EC 1.14.16.1) activity, but appear to result from a generalized movement of amino acids from muscle to liver during infection.

摘要

大鼠兔热病会导致血清苯丙氨酸/酪氨酸比值翻倍，肌肉中苯丙氨酸增加两倍多，这不能用肝脏苯丙氨酸羟化酶（EC 1.14.16.1）活性降低来解释，而似乎是感染期间氨基酸从肌肉向肝脏普遍转移的结果。

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Distribution and metabolism of phenylalanine and tyrosine during tualraemia in the rat.大鼠患血紫质病期间苯丙氨酸和酪氨酸的分布与代谢
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引用本文的文献

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Stereotypic responses to infection and inflammation: probable activation of phagocytic cells.对感染和炎症的刻板反应：吞噬细胞可能被激活。
Inflammation. 1982 Jun;6(2):137-46. doi: 10.1007/BF00916238.
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Role of the liver in regulation of ketone body production during sepsis.肝脏在脓毒症期间酮体生成调节中的作用。
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本文引用的文献

1
Protein metabolism in infection. I. Changes in certain visceral proteins studied with glycine-N 15.感染中的蛋白质代谢。I. 用甘氨酸-N¹⁵研究某些内脏蛋白质的变化。
Metabolism. 1959 Mar;8(2):151-9.
2
p-Chlorophenylalanine-induced chemical manifestations of phenylketonuria in rats.对氯苯丙氨酸诱发大鼠苯丙酮尿症的化学表现
Science. 1967 Apr 14;156(3772):248-50. doi: 10.1126/science.156.3772.248.
3
The early treatment of phenylketonuria.苯丙酮尿症的早期治疗。
Am J Dis Child. 1967 Jan;113(1):16-21. doi: 10.1001/archpedi.1967.02090160066004.
4
Effect of infection on protein and nucleic acid synthesis in mammalian organs and tissues.感染对哺乳动物器官和组织中蛋白质及核酸合成的影响。
Fed Proc. 1966 Nov-Dec;25(6):1688-94.
5
An endogenous mediator of depression of amino acids and trace metals in serum during typhoid fever.伤寒热期间血清中氨基酸和微量元素抑郁的内源性介质。
J Infect Dis. 1972 Jul;126(1):77-86. doi: 10.1093/infdis/126.1.77.
6
Effects of infection on selected clinical and biochemical parameters in dogs.感染对犬类特定临床和生化参数的影响。
Br J Exp Pathol. 1970 Jun;51(3):253-64.
7
Changes in individual plasma amino acids following experimentally induced and fly fever virus infection.实验性诱导发热和感染蝇热病毒后个体血浆氨基酸的变化。
Metabolism. 1972 Jan;21(1):67-76. doi: 10.1016/0026-0495(72)90021-2.
8
Mediator of hepatic amino acid flux in infected rats.感染大鼠肝脏氨基酸通量的介质
Proc Soc Exp Biol Med. 1972 Jan;139(1):128-32. doi: 10.3181/00379727-139-36094.
9
Nitrogen metabolism and protein synthesis during pneumococcal sepsis in rats.大鼠肺炎球菌败血症期间的氮代谢与蛋白质合成
Infect Immun. 1972 Sep;6(3):266-71. doi: 10.1128/iai.6.3.266-271.1972.
10
Tissue amino acid flux after exposure of rats to Diplococcus pneumoniae.大鼠暴露于肺炎双球菌后组织氨基酸通量
Infect Immun. 1971 Nov;4(5):556-62. doi: 10.1128/iai.4.5.556-562.1971.