Eddleston A L
Postgrad Med J. 1974 Jun;50(584):348-53. doi: 10.1136/pgmj.50.584.348.
Studies of asymptomatic carriers of hepatitis B antigen (HB Ag) have suggested that the hepatitis B virus may not be directly damaging to liver cells and it is possible that the hepatocellular necrosis which accompanies acute hepatitis may be induced by immunological reactions directed at viral antigenic determinants on the surface of infected cells. Immunological reactions may also be implicated in the pathogenesis of active chronic hepatitis. Although antibodies which are commonly present in the serum are probably not of primary importance in the immunopathology, recent studies have demonstrated liver-specific immune responses, both humoral and cellular, which may be more directly related to the pathogenesis.
对乙型肝炎抗原（HB Ag）无症状携带者的研究表明，乙肝病毒可能不会直接损害肝细胞，急性肝炎时伴随出现的肝细胞坏死有可能是针对受感染细胞表面病毒抗原决定簇的免疫反应所诱发的。免疫反应也可能与活动性慢性肝炎的发病机制有关。虽然血清中常见的抗体在免疫病理学中可能并非至关重要，但最近的研究已经证实了肝脏特异性免疫反应，包括体液免疫和细胞免疫，而这些反应可能与发病机制更直接相关。
