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酮康唑——一种新型口服活性广谱抗真菌药。

Ketoconazole -- a new broad spectrum orally active antimycotic.

作者信息

Thienpont D, Van Cutsem J, Van Gerven F, Heeres J, Janssen P A

出版信息

Experientia. 1979 May 15;35(5):606-7. doi: 10.1007/BF01960348.

DOI:10.1007/BF01960348
PMID:446651
Abstract

Oral treatment with ketoconazole prevented and cured artificial crop candidosis of the turkey, vaginal candidosis of the rat and skin candidosis of the guinea-pig. It was also highly effective against artificial systemic candidosis of the guinea-pig and chicken as well as against dermatophytoses of the guinea-pig.

摘要

口服酮康唑可预防和治愈火鸡的人工嗉囊念珠菌病、大鼠的阴道念珠菌病和豚鼠的皮肤念珠菌病。它对豚鼠和鸡的人工系统性念珠菌病以及豚鼠的皮肤癣菌病也非常有效。

相似文献

1
Ketoconazole -- a new broad spectrum orally active antimycotic.酮康唑——一种新型口服活性广谱抗真菌药。
Experientia. 1979 May 15;35(5):606-7. doi: 10.1007/BF01960348.
2
[Ketoconazole. 3 years' experience with a new orally active broadspectrum antimycotic].[酮康唑。新型口服活性广谱抗真菌药的三年使用经验]
Z Hautkr. 1982 Aug 15;57(16):1165-76.
3
The antifungal activity of ketoconazole.酮康唑的抗真菌活性。
Am J Med. 1983 Jan 24;74(1B):9-15. doi: 10.1016/0002-9343(83)90508-9.
4
Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections.酮康唑：对其在浅表和全身性真菌感染中治疗效果的综述。
Drugs. 1982 Jan-Feb;23(1-2):1-36. doi: 10.2165/00003495-198223010-00001.
5
Miconazole, a broad-spectrum antimycotic agent with antibacterial activity.咪康唑，一种具有抗菌活性的广谱抗真菌剂。
Chemotherapy. 1972;17(6):392-404. doi: 10.1159/000220875.
6
Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent.抗真菌咪唑类。第4部分。酮康唑的合成及抗真菌活性，一种新型强效口服活性广谱抗真菌剂。
J Med Chem. 1979 Aug;22(8):1003-5. doi: 10.1021/jm00194a023.
7
Ketoconazole: a major innovation for treatment of fungal disease.酮康唑：治疗真菌病的一项重大创新。
Ann Intern Med. 1980 Dec;93(6):921-3. doi: 10.7326/0003-4819-93-6-921.
8
Experimental in vitro and in vivo comparison of modern antimycotics.现代抗真菌药物的体外和体内实验比较
Curr Med Res Opin. 1977;5(4):315-27. doi: 10.1185/03007997709110187.
9
Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: animal models.口服、局部及胃肠外给药的伊曲康唑在治疗浅表及深部真菌病中的活性：动物模型
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S15-32. doi: 10.1093/clinids/9.supplement_1.s15.
10
Antimycotic activity of BAY N 7133 in animal experiments.BAY N 7133在动物实验中的抗真菌活性。
J Antimicrob Chemother. 1984 May;13(5):447-63. doi: 10.1093/jac/13.5.447.

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Comparative assessment of the efficacy of topical ketoconazole and topical luliconazole in cases of pityriasis versicolor at a tertiary care hospital in eastern India: A prospective, open, randomized controlled trial.印度东部一家三级护理医院中局部用酮康唑与局部用卢立康唑治疗花斑糠疹疗效的比较评估：一项前瞻性、开放性、随机对照试验。
Indian Dermatol Online J. 2016 Jul-Aug;7(4):335-6. doi: 10.4103/2229-5178.185471.
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Conazoles.康唑类药物。
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Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats.

本文引用的文献

1
Experimental cutaneous Candida albicans infection in guinea-pigs.豚鼠皮肤白色念珠菌感染实验
Sabouraudia. 1971 Mar;9(1):17-20.
2
The preparation and antimycotic properties of derivatives of 1-phenethylimidazole.
J Med Chem. 1969 Sep;12(5):784-91. doi: 10.1021/jm00305a014.
3
Miconazole, a broad-spectrum antimycotic agent with antibacterial activity.咪康唑，一种具有抗菌活性的广谱抗真菌剂。
Chemotherapy. 1972;17(6):392-404. doi: 10.1159/000220875.
甲吡酮与奥沙西泮联合使用对大鼠可卡因及食物自我给药的影响。
Pharmacol Biochem Behav. 2008 Nov;91(1):181-9. doi: 10.1016/j.pbb.2008.07.005. Epub 2008 Jul 19.
4
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections.高通量协同筛选确定微生物代谢产物为治疗真菌感染的联合用药。
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4606-11. doi: 10.1073/pnas.0609370104. Epub 2007 Mar 5.
5
An overview of topical antifungal therapy in dermatomycoses. A North American perspective.皮肤真菌病的局部抗真菌治疗概述。北美视角。
Drugs. 1998 May;55(5):645-74. doi: 10.2165/00003495-199855050-00004.
6
Effect of ketoconazole and amphotericin B on encapsulated and non-encapsulated strains of Cryptococcus neoformans.酮康唑和两性霉素B对新型隐球菌有荚膜和无荚膜菌株的影响。
Antimicrob Agents Chemother. 1983 Dec;24(6):851-5. doi: 10.1128/AAC.24.6.851.
7
Effects of pH on the activity of ketoconazole against Candida albicans.pH对酮康唑抗白色念珠菌活性的影响。
Antimicrob Agents Chemother. 1983 Jan;23(1):105-7. doi: 10.1128/AAC.23.1.105.
8
Combined activity of ketoconazole and 5-fluorocytosine on potentially pathogenic yeasts.酮康唑与5-氟胞嘧啶对潜在致病性酵母的联合活性。
Antimicrob Agents Chemother. 1982 Feb;21(2):355-7. doi: 10.1128/AAC.21.2.355.
9
Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections.酮康唑：对其在浅表和全身性真菌感染中治疗效果的综述。
Drugs. 1982 Jan-Feb;23(1-2):1-36. doi: 10.2165/00003495-198223010-00001.
10
In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis.抗真菌药物酮康唑对甾醇合成的体外和体内作用。
Antimicrob Agents Chemother. 1980 Jun;17(6):922-8. doi: 10.1128/AAC.17.6.922.
4
Synthesis and antimyoctic properties of 1-(2-alkyl-2-phenylethyl)-1H-imidazoles.1-(2-烷基-2-苯乙基)-1H-咪唑的合成及其抗真菌特性
J Med Chem. 1976 Sep;19(9):1148-55. doi: 10.1021/jm00231a013.