pH对酮康唑抗白色念珠菌活性的影响。
Effects of pH on the activity of ketoconazole against Candida albicans.
作者信息
Minagawa H, Kitaura K, Nakamizo N
出版信息
Antimicrob Agents Chemother. 1983 Jan;23(1):105-7. doi: 10.1128/AAC.23.1.105.
Abstract
The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 mug/ml at pH 3 to 0.02 mug/ml at pH 7, a greater than 1,000-fold difference.
摘要
酮康唑在沙氏葡萄糖培养基中对白色念珠菌的活性受到pH值的显著影响。这种咪唑类药物对标准菌株和临床分离株的最低抑菌浓度范围为，在pH 3时为40微克/毫升，在pH 7时为0.02微克/毫升，相差超过1000倍。
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