抗真菌咪唑类。第4部分。酮康唑的合成及抗真菌活性，一种新型强效口服活性广谱抗真菌剂。
Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent.
作者信息
Heeres J, Backx L J, Mostmans J H, Van Cutsem J
出版信息
J Med Chem. 1979 Aug;22(8):1003-5. doi: 10.1021/jm00194a023.
PMID:490531
Abstract
The preparation and antifungal properties of cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine (I) are described. Ketoconazole has, at low oral doses, a high in vivi activity against vaginal candidosis in rats and against cutaneous candidosis in guinea pigs.
摘要
描述了顺式-1-乙酰基-4-[4-[[2-(2,4-二氯苯基)-2-(1H-咪唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪（I）的制备及其抗真菌特性。酮康唑在低口服剂量时，对大鼠阴道念珠菌病和豚鼠皮肤念珠菌病具有高体内活性。
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