Ficek W
Z Mikrosk Anat Forsch. 1982;96(4):720-30.
Adult male rats were intraperitoneally administered aqueous solution of lithium chloride (LiCl). Studies, including neurosecretory and microstructural changes within particular neurocytes in supraoptic (NSO) and paraventricular nuclei (NPV) were performed on hypothalamic sections. In the experimental rats the administered LiCl increased the level of GOMORI-positive neurosecretory material both in supraoptic and paraventricular nuclei. Great amounts of the neurosecretory material were markedly conspicuous in the above areas after 20 days of LiCl administration. Investigations carried out on cellular nuclei of particular neurocytes showed a significant enlargement of the nuclei, and statistical calculations revealed that, in comparison with the basic control, the difference was essentially significant (p less than 0.001). 3H-thymidin administration to the rats which had previously been on LiCl for 20 days demonstrated also that within supraoptic nuclei the incorporation of the isotope in cellular nuclei took a faster course than in control animals.
成年雄性大鼠腹腔注射氯化锂水溶液。对下丘脑切片进行了研究，包括对视上核（NSO）和室旁核（NPV）中特定神经细胞内的神经分泌和微观结构变化。在实验大鼠中，给予的氯化锂增加了视上核和室旁核中GOMORI阳性神经分泌物质的水平。在给予氯化锂20天后，上述区域大量的神经分泌物质明显可见。对特定神经细胞的细胞核进行的研究表明，细胞核显著增大，统计计算显示，与基础对照组相比，差异具有显著性意义（p小于0.001）。对先前已给予氯化锂20天的大鼠给予3H-胸腺嘧啶核苷也表明，视上核内同位素在细胞核中的掺入过程比对照动物更快。
