Eastwood J B, Gower P E
Postgrad Med J. 1974 Nov;50(589):710-2. doi: 10.1136/pgmj.50.589.710.
A single dose of 150 mg clindamycin was given to nine patients with terminal renal failure being treated by maintenance haemodialysis and the blood levels were measured. Four of these patients were studied during haemodialysis and five between haemodialyses. Clindamycin (150 mg) was also given orally to four normal subjects. The mean serum half-life in the normal subjects was 2·15 hr. For the dialysis patients the mean serum half-life off dialysis was 1·58 hr while that on dialysis was 1·85 hr. There is evidence that clindamycin is excreted normally in chronic renal failure and that blood levels are not affected by haemodialysis. Normal adult doses, 150-300 mg four times a day, can be given safely in patients with chronic renal failure.
给9名接受维持性血液透析治疗的终末期肾衰竭患者单次静脉注射150mg克林霉素，并测定血药浓度。其中4名患者在血液透析期间接受研究，5名患者在非透析期间接受研究。还对4名正常受试者口服150mg克林霉素。正常受试者的平均血清半衰期为2.15小时。透析患者非透析期间的平均血清半衰期为1.58小时，透析期间为1.85小时。有证据表明，克林霉素在慢性肾衰竭患者中排泄正常，且血药浓度不受血液透析的影响。慢性肾衰竭患者可安全给予正常成人剂量，即每日4次，每次150 - 300mg。
