Cimino J E, Tierno P M
Appl Microbiol. 1969 Mar;17(3):446-8. doi: 10.1128/am.17.3.446-448.1969.
The effect of hemodialysis (Kolff-type machine) on clindamycin blood levels in anuric patients was studied. At 1 hr after oral ingestion of drug, blood levels ranged from 1.23 to 5.17 mug/ml and fell thereafter. Half-times for peripheral removal were 3.36 mug/ml +/- 0.22 when subjects were "off" dialysis and 3.14 mug/ml +/- 0.09 during dialysis. Their difference was not statistically significant, indicating that hemodialysis does not affect the blood level of clindamycin. In all studies, significant levels of the antibiotic were present at 12 hr.
研究了血液透析（科尔夫型机器）对无尿患者克林霉素血药浓度的影响。口服药物1小时后，血药浓度范围为1.23至5.17微克/毫升，此后下降。当受试者“未进行”透析时，外周血清除半衰期为3.36微克/毫升±0.22，透析期间为3.14微克/毫升±0.09。它们之间的差异无统计学意义，表明血液透析不影响克林霉素的血药浓度。在所有研究中，12小时时抗生素浓度仍处于显著水平。
