Fischer V W, Barner H B, Leskiw M L
Diabetes. 1979 Aug;28(8):713-9. doi: 10.2337/diab.28.8.713.
Biopsied myocardial tissue was obtained from 24 patients electing coronary arterial bypass surgery who were divided into three groups: chemical diabetics (CD) with normal fasting blood sugar levels and incidentally encountered elevated glucose levels after sugar loading; overt diabetics (OD) requiring insulin treatment; and euglycemic, nondiabetic patients (ND) serving as a control group. Specimens from the left anterior apical segment of the heart were processed for ultrastructural examination, with special emphasis on determining capillary basal laminar thickness with the aid of morphometric techniques. Results of this study indicate that (1) a statistically significant increase in basal laminar thickness is evident in myocardial tissue of OD patients; (2) incipient alterations in laminar width are demonstrable in the CD group; (3) the predominant morphologic abnormalities, which we have examined in the parenchymal tissue of the biopsied hearts, namely myocardial hypertrophy and interstitial fibrosis, are present to a comparable degree in all three groups of patients; and (4) the average thickness of basal laminae around myocardial capillaries tends to be narrower compared with measurements reported in other tissue compartments.
从24例选择冠状动脉搭桥手术的患者获取心肌活检组织，这些患者被分为三组：空腹血糖水平正常但糖负荷后偶然出现血糖升高的化学性糖尿病患者（CD）；需要胰岛素治疗的显性糖尿病患者（OD）；以及血糖正常的非糖尿病患者（ND）作为对照组。取自心脏左前心尖段的标本进行超微结构检查，特别强调借助形态计量技术确定毛细血管基底膜厚度。本研究结果表明：（1）OD患者心肌组织中基底膜厚度有统计学意义的显著增加；（2）CD组可显示基底膜宽度的早期改变；（3）我们在活检心脏实质组织中检查的主要形态学异常，即心肌肥大和间质纤维化，在所有三组患者中程度相当；（4）与其他组织区域报道的测量值相比，心肌毛细血管周围基底膜的平均厚度往往更窄。
