[不同脑结构中凝血活酶活性与其中功能不同的磷脂类群的定量相互关系之间的联系]
[Relationship between thromboplastin activity in different brain structures and the quantitative interrelationships of functionally different groups of phospholipids in them].
作者信息
Pogosbekova S D, Karagezian K G
出版信息
Vopr Biokhim Mozga. 1974;9:65-74.
The microsomal fraction of rabbit brain has the highest content of phospholipids and is completely devoid of polyglycerophospholipids. The decrease of the ratio of neutral to acid phospholipids is accompanied by a corresponding reduction of thromboplastic activity. Thromboplastic activity is high in the nuclear fraction of the medulla oblongata, cerebellum and cerebral hemispheres. Adrenaline reduces the amount of both total and individual phospholipids (mainly neutral) in subcellular particles of brain. This is accompanied by reduction of thromboplastic activity. The incubation of homogenates of brain parts for 2 hrs in the presence of glucose brings to the increase of phospholipids in the incubation medium and enhancement of thromboplastic activity.
兔脑微粒体部分的磷脂含量最高，且完全不含聚甘油磷脂。中性磷脂与酸性磷脂比例的降低伴随着凝血活性相应降低。延髓、小脑和大脑半球的核部分凝血活性较高。肾上腺素会降低脑亚细胞颗粒中总磷脂和个别磷脂（主要是中性磷脂）的含量，同时凝血活性也会降低。在有葡萄糖存在的情况下，将脑部匀浆孵育2小时会使孵育介质中的磷脂增加，凝血活性增强。
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