花生四烯酸如何降低胸腺重量。

How arachidonic acid depresses thymus weight.

作者信息

Meade C J

出版信息

Int Arch Allergy Appl Immunol. 1979;59(4):432-6. doi: 10.1159/000232291.

Abstract

Subcutaneous injection of arachidonic acid depresses thymus weight. This is unlikely to be a stress effect, since arachidonic acid is equally active in adrenalectomised animals. Amongst other fatty acids tested, those capable of being metabolised to arachidonic acid have greater thymolytic activity than those which are not arachidonic acid precursors. Thymolysis is significantly inhibited by indomethacin, a drug which blocks the conversion of arachidonic acid to prostaglandins.

摘要

皮下注射花生四烯酸会使胸腺重量减轻。这不太可能是应激效应，因为花生四烯酸在肾上腺切除的动物中同样具有活性。在测试的其他脂肪酸中，那些能够代谢为花生四烯酸的脂肪酸比那些不是花生四烯酸前体的脂肪酸具有更强的胸腺溶解活性。消炎痛（一种阻断花生四烯酸转化为前列腺素的药物）能显著抑制胸腺溶解。