Cynader M
Invest Ophthalmol Vis Sci. 1979 Jul;18(7):726-41.
Kittens were placed in the dark just after birth and then removed at various ages for the study of interocular alignment. It was found that kittens dark-reared for 4 months or longer were characteristically incyclotorted with respect to normal animals. Deprivation periods of less than 2 months were ineffective in producing these changes. Divergence of the visual axes was also observed in some dark-reared cats. Pupillary constriction in response to light was much more pronounced in dark-reared cats than in normal cats. This enhanced pupillary reaction persisted for at least 3 weeks after the deprived animals were brought into an illuninated environment. When dark-reared cats were allowed a recovery period in a normally lit visual environment, their ocular alignment changed markedly. The incyclotorsion and divergence of the visual axes disappeared, and instead cats allowed recovery from deprivation could display excyclotorsion and/or convergence of the visual axes. These anomalies of ocular alignment associated with the recovery from visual deprivation could occur following periods of initial deprivation as short as 30 days or as long as 2 years. The mechanisms and possible significance of such anomalies are considered.
小猫在出生后即刻被置于黑暗环境中，然后在不同年龄取出以研究眼间对齐情况。结果发现，与正常动物相比，黑暗饲养4个月或更长时间的小猫通常会出现眼球内旋扭转。剥夺期少于2个月则无法产生这些变化。在一些黑暗饲养的猫中还观察到视轴发散。黑暗饲养的猫对光的瞳孔收缩比正常猫明显得多。这种增强的瞳孔反应在被剥夺的动物进入光照环境后至少持续3周。当黑暗饲养的猫在正常光照的视觉环境中被给予恢复期时，它们的眼间对齐会发生明显变化。眼球内旋扭转和视轴发散消失，相反，从剥夺状态恢复的猫可能会出现眼球外旋扭转和/或视轴会聚。与视觉剥夺恢复相关的这种眼间对齐异常可能在最初剥夺期短至30天或长达2年之后出现。本文考虑了此类异常的机制及可能的意义。
