Harrison P M, Hoy T G, Macara I G, Hoare R J
Biochem J. 1974 Nov;143(2):445-51. doi: 10.1042/bj1430445.
Iron uptake and release by ferritin molecules of different iron contents show similar profiles. These are discussed in relation to the structure of the ferritin molecule. Two models of iron uptake and release are considered. One involves iron oxidation-reduction sites on the protein. The other allows direct interaction of reagents with the iron-core crystallites. It is concluded that the second model accounts better for the experimental results presented now and in previous publications.
不同铁含量的铁蛋白分子对铁的摄取和释放呈现出相似的特征。结合铁蛋白分子的结构对这些特征进行了讨论。考虑了两种铁摄取和释放模型。一种涉及蛋白质上的铁氧化还原位点。另一种则允许试剂与铁芯微晶直接相互作用。得出的结论是,第二种模型能更好地解释目前以及之前出版物中所呈现的实验结果。