• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对脊髓麻醉大鼠肝脏中普萘洛尔首过消除的影响。
Br J Pharmacol. 1982 Dec;77(4):667-77. doi: 10.1111/j.1476-5381.1982.tb09345.x.
2
Inhibition of soybean lipoxygenase by SKF 525-A and metyrapone.SKF 525 - A和甲吡酮对大豆脂氧合酶的抑制作用
Prostaglandins. 1985 Oct;30(4):591-8. doi: 10.1016/0090-6980(85)90023-1.
3
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver.炎症和丙胺太林对大鼠离体灌流肝脏中安替比林、利多卡因和普萘洛尔处置的影响。
J Pharm Pharmacol. 1987 Dec;39(12):997-1002. doi: 10.1111/j.2042-7158.1987.tb03147.x.
4
Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes.炎症对离体大鼠肝细胞中安替比林、利多卡因和普萘洛尔代谢的影响。
Pharmacology. 1988;36(4):279-82. doi: 10.1159/000138395.
5
Effects of chlorpromazine, imipramine and baclofen on the spinal polysynaptic reflex in acute, chronic and 6-hydroxydopamine-treated spinal rats.氯丙嗪、丙咪嗪和巴氯芬对急性、慢性及6-羟基多巴胺处理的脊髓大鼠脊髓多突触反射的影响。
Jpn J Pharmacol. 1982 Dec;32(6):1125-33. doi: 10.1254/jjp.32.1125.
6
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.细胞色素P - 450在β受体阻断药肝脏“首过消除”中的可能作用。
Acta Pharmacol Toxicol (Copenh). 1974 Sep;35(3):242-60. doi: 10.1111/j.1600-0773.1974.tb00744.x.
7
Uptake of propranolol by the lung and its displacement by other drugs: involvement of the alveolar macrophage.普萘洛尔在肺中的摄取及其被其他药物取代：肺泡巨噬细胞的作用
Pharmacology. 1980;20(5):275-83. doi: 10.1159/000137373.
8
Drug metabolism in isolated rat liver cells.大鼠离体肝细胞中的药物代谢
Adv Exp Med Biol. 1975;58(00):251-69.
9
Effects of chlorpromazine on the disposition and beta-adrenergic blocking activity of propranolol in the dog.氯丙嗪对狗体内普萘洛尔的处置及β-肾上腺素能阻断活性的影响。
J Pharmacokinet Biopharm. 1984 Jun;12(3):333-49. doi: 10.1007/BF01061724.
10
Effect of metyrapone on tryptophan binding to rat hepatic nuclei.
Metabolism. 1994 Jan;43(1):79-84. doi: 10.1016/0026-0495(94)90160-0.

引用本文的文献

1
Endothelium is required in the vascular spasm induced by tetraethylammonium and endothelin-1 in guinea-pig aorta.豚鼠主动脉中由四乙铵和内皮素-1诱导的血管痉挛需要内皮细胞。
Br J Pharmacol. 1999 May;127(2):505-13. doi: 10.1038/sj.bjp.0702557.
2
Effects of chlorpromazine on the disposition and beta-adrenergic blocking activity of propranolol in the dog.氯丙嗪对狗体内普萘洛尔的处置及β-肾上腺素能阻断活性的影响。
J Pharmacokinet Biopharm. 1984 Jun;12(3):333-49. doi: 10.1007/BF01061724.
3
The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats.
Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):221-8. doi: 10.1007/BF03190102.

本文引用的文献

1
Inhibitory effects of beta-diethylaminoethyl diphenylpropylacetate on a variety of drug metabolic pathways in vitro.β-二乙氨基乙基二苯基丙基乙酸酯对多种药物代谢途径的体外抑制作用。
J Pharmacol Exp Ther. 1954 Sep;112(1):55-63.
2
4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol.单次及长期服用普萘洛尔后的4-羟基普萘洛尔及其葡糖醛酸苷。
Clin Pharmacol Ther. 1980 Jan;27(1):22-31. doi: 10.1038/clpt.1980.4.
3
Pharmacokinetic interaction between propranolol and chlorpromazine in schizophrenic patients.精神分裂症患者中普萘洛尔与氯丙嗪的药代动力学相互作用。
Lancet. 1980 Nov 1;2(8201):978. doi: 10.1016/s0140-6736(80)92135-2.
4
Change in colloidal gold clearance in rats treated with SKF 525-A.用SKF 525 - A处理的大鼠胶体金清除率的变化。
Rev Can Biol. 1970 Sep;29(3):294-8.
5
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
6
A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.一种在脊髓被破坏的猫和大鼠中刺激从脊柱到各个器官的自主神经传出不同节段的方法。
Br J Pharmacol. 1970 Oct;40(2):257-67. doi: 10.1111/j.1476-5381.1970.tb09919.x.
7
The disposition of propranolol. II. Hepatic elimination in the rat.普萘洛尔的处置。II. 大鼠的肝脏消除
Pharmacology. 1972;8(4):344-52. doi: 10.1159/000136352.
8
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.甲吡酮与细胞色素P - 450的结合及其对肝微粒体混合功能氧化反应的抑制作用。
Biochem Soc Symp. 1972;34:79-102.
9
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.细胞色素P - 450在β受体阻断药肝脏“首过消除”中的可能作用。
Acta Pharmacol Toxicol (Copenh). 1974 Sep;35(3):242-60. doi: 10.1111/j.1600-0773.1974.tb00744.x.
10
Effects of metyrapone on liver microsomal drug oxidations.甲吡酮对肝脏微粒体药物氧化的影响。
Mol Pharmacol. 1969 Jan;5(1):1-9.

氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对脊髓麻醉大鼠肝脏中普萘洛尔首过消除的影响。

The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.

作者信息

Barber H E, Kitteringham N R, Petrie J C

出版信息

Br J Pharmacol. 1982 Dec;77(4):667-77. doi: 10.1111/j.1476-5381.1982.tb09345.x.

DOI:10.1111/j.1476-5381.1982.tb09345.x
PMID:7150874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044668/
Abstract

1 The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol has been studied in the pithed rat. 2 The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the inhibition caused by propranolol of an elicited electrically induced tachycardia has also been studied. 3 The hepatic first pass elimination of propranolol was reduced following pretreatment with chlorpromazine, imipramine and SKF 525-A but was not affected by pretreatment with metyrapone. 4 Chlorpromazine, imipramine and SKF 525-A all resulted in an increased propranolol blood concentration after hepatic portal vein administration which was associated with decreased formation of metabolites and an enhanced inhibition of an electrically induced tachycardia.

摘要
  1. 已在麻醉大鼠中研究了氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对普萘洛尔肝首过消除的影响。2. 还研究了氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对普萘洛尔引起的诱发电致心动过速抑制作用的影响。3. 氯丙嗪、丙咪嗪和SKF 525 - A预处理后，普萘洛尔的肝首过消除减少，但甲吡酮预处理对其无影响。4. 氯丙嗪、丙咪嗪和SKF 525 - A在肝门静脉给药后均导致普萘洛尔血药浓度升高，这与代谢物形成减少和电致心动过速抑制增强有关。