氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对脊髓麻醉大鼠肝脏中普萘洛尔首过消除的影响。
The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.
作者信息
Barber H E, Kitteringham N R, Petrie J C
出版信息
Br J Pharmacol. 1982 Dec;77(4):667-77. doi: 10.1111/j.1476-5381.1982.tb09345.x.
Abstract
1 The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol has been studied in the pithed rat. 2 The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the inhibition caused by propranolol of an elicited electrically induced tachycardia has also been studied. 3 The hepatic first pass elimination of propranolol was reduced following pretreatment with chlorpromazine, imipramine and SKF 525-A but was not affected by pretreatment with metyrapone. 4 Chlorpromazine, imipramine and SKF 525-A all resulted in an increased propranolol blood concentration after hepatic portal vein administration which was associated with decreased formation of metabolites and an enhanced inhibition of an electrically induced tachycardia.
摘要
- 已在麻醉大鼠中研究了氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对普萘洛尔肝首过消除的影响。2. 还研究了氯丙嗪、甲吡酮、丙咪嗪和SKF 525 - A对普萘洛尔引起的诱发电致心动过速抑制作用的影响。3. 氯丙嗪、丙咪嗪和SKF 525 - A预处理后，普萘洛尔的肝首过消除减少，但甲吡酮预处理对其无影响。4. 氯丙嗪、丙咪嗪和SKF 525 - A在肝门静脉给药后均导致普萘洛尔血药浓度升高，这与代谢物形成减少和电致心动过速抑制增强有关。
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