Nazzaro-Porro M, Passi S, Balus L, Breathnach A, Martin B, Morpurgo G
J Invest Dermatol. 1979 Jun;72(6):296-305. doi: 10.1111/1523-1747.ep12531744.
Dicarboxylic acids from C8 to C14 are competitive inhibitors of tyrosinase in vitro, and here, the effect of a cream containing 15% azelaic acid (C9) on 3 cases of lentigo maligna is described. The lesions were treated for 90 days, with remarkable clinical and histological effect, maintained for up to 2 yr after cessation of treatment. Progress during treatment of one case was additionally monitored by electron microscopy, which revealed progressive elimination of abnormal melanocytes both basally and suprabasally, and their replacement by essentially normal cells engaged in normal melanogenesis. There was also progressive diminution in the general disorganization of the epidermis, and disappearance of lymphocyte response. It is concluded that dicarboxylic acids have a direct inhibitory and cytotoxic effect on abnormally active or structurally disordered melanocytes in lentigo maligna, but further investigations are required to establish their precise mode of action. Similar application of dicarboxylic acids to normal skin affects only a small proportion of melanocytes, suggesting that some phasic factor, or individual states of activity, may be concerned in their susceptibility.
C8至C14的二羧酸在体外是酪氨酸酶的竞争性抑制剂，在此描述了一种含15%壬二酸（C9）的乳膏对3例恶性雀斑样痣的疗效。对皮损治疗90天，取得了显著的临床和组织学效果，在治疗停止后维持长达2年。通过电子显微镜对1例患者治疗过程中的进展进行了额外监测，结果显示基底和基底上层的异常黑素细胞逐渐被清除，并被参与正常黑素生成的基本正常的细胞所取代。表皮的整体紊乱也逐渐减轻，淋巴细胞反应消失。得出的结论是，二羧酸对恶性雀斑样痣中异常活跃或结构紊乱的黑素细胞具有直接抑制和细胞毒性作用，但需要进一步研究以确定其确切作用方式。二羧酸在正常皮肤上的类似应用仅影响一小部分黑素细胞，这表明某些阶段性因素或个体活性状态可能与其敏感性有关。
