Bartoletti A L, Stevenson D K, Ostrander C R, Johnson J D
J Pediatr. 1979 Jun;94(6):952-5. doi: 10.1016/s0022-3476(79)80231-0.
Using a single pass, flow-through system, the pulmonary excretion rate of endogenously produced carbon monoxide was measured as an index of bilirubin production in human infants with varying gestational and postnatal ages and with a variety of clinical abnormalities. No significant difference in VECO was found related to sex or gestational age. The mean VECO for a small group of Oriental infants was significantly increased. VECO decreased with increasing postnatal age. As expected, infants with hemolytic disease of the newborn had a markedly increased mean VECO. Infants with jaundice of unknown etiology also had an elevated mean VECO, implying that increased bilirubin production may be a factor contributing to the "nonphysiologic" bilirubinemias of these infants.
采用单次通过、流通式系统，以内源性产生的一氧化碳的肺排泄率作为指标，对不同胎龄、出生后年龄及患有各种临床异常情况的人类婴儿的胆红素生成情况进行了测量。未发现一氧化碳肺排泄率（VECO）在性别或胎龄方面存在显著差异。一小群东方婴儿的平均VECO显著升高。VECO随出生后年龄的增加而降低。正如预期的那样，患有新生儿溶血病的婴儿平均VECO显著升高。病因不明的黄疸婴儿平均VECO也升高，这意味着胆红素生成增加可能是导致这些婴儿“非生理性”高胆红素血症的一个因素。
