Cohen R S, Ostrander C R, Cowan B E, Stevens G B, Hopper A O, Stevenson D K
Biol Neonate. 1982;41(5-6):289-93. doi: 10.1159/000241564.
The pathophysiology of the exaggerated hyperbilirubinemia in premature infants remains unclear. The relative contribution of bilirubin production may be estimated by measuring the pulmonary excretion rate of carbon monoxide (VeCO). We found that the mean VeCO of premature infants, 16.7 +/- 5.0 microliters/kg/h, was significantly elevated (p less than 0.05) compared with the mean VeCO of full-term infants, 13.9 +/- 3.5 microliters/kg/h. Premature infants who required phototherapy had a significantly (p less than 0.05) higher mean VeCO than those who did not. The VeCO did not correlate with gestational age, implying that factors which associate frequently but variably with gestational age may have an important influence on heme catabolism.
早产儿出现的高胆红素血症的病理生理机制尚不清楚。胆红素生成的相对贡献可通过测量一氧化碳的肺排泄率（VeCO）来估算。我们发现，早产儿的平均VeCO为16.7±5.0微升/千克/小时，与足月儿的平均VeCO（13.9±3.5微升/千克/小时）相比显著升高（p<0.05）。需要光疗的早产儿的平均VeCO显著高于（p<0.05）不需要光疗的早产儿。VeCO与胎龄无关，这意味着那些与胎龄经常但变化相关的因素可能对血红素分解代谢有重要影响。
