干扰素对致敏淋巴细胞特异性细胞毒性的增强作用。
Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes.
作者信息
Lindahl P, Leary P, Gresser I
出版信息
Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5. doi: 10.1073/pnas.69.3.721.
Abstract
Mouse interferon preparations enhanced the specific cytotoxicity of sensitized lymphocytes for allogeneic target tumor cells. The factor responsible for the enhancement of cytotoxicity could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Thus, in addition to its well-known antiviral activity, and its effect on cell division, interferon also appears to enhance a specialized cellular function. It is suggested that a common mechanism of action underlies these seemingly different biologic phenomena, and that interferon may play a role in the regulation of fundamental cellular processes.
摘要
小鼠干扰素制剂增强了致敏淋巴细胞对同种异体靶肿瘤细胞的特异性细胞毒性。通过标准物理化学方法，无法将负责增强细胞毒性的因子与干扰素的抗病毒活性分离。因此，除了其众所周知的抗病毒活性及其对细胞分裂的影响外，干扰素似乎还能增强一种特殊的细胞功能。有人提出，这些看似不同的生物学现象背后存在一个共同的作用机制，并且干扰素可能在基本细胞过程的调节中发挥作用。
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Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes.干扰素对致敏淋巴细胞特异性细胞毒性的增强作用。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5. doi: 10.1073/pnas.69.3.721.
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Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells.干扰素对小鼠白血病L 1210细胞表面抗原表达的增强作用。
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本文引用的文献
1
Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.悬浮L细胞中病毒干扰的定量研究。III. 干扰病毒和干扰素对细胞生长速率的影响。
Virology. 1962 Jun;17:324-34. doi: 10.1016/0042-6822(62)90123-x.
2
INTERFERON.干扰素
Adv Virus Res. 1963;10:1-38.
3
THE ROLE OF THE RETICULOENDOTHELIAL SYSTEM IN INTERFERON FORMATION IN THE RABBIT.网状内皮系统在兔体内干扰素形成中的作用
Virology. 1965 Jan;25:163-6. doi: 10.1016/0042-6822(65)90268-0.
4
A RICH SOURCE OF MOUSE INTERFERON.小鼠干扰素的丰富来源。
Nature. 1964 Dec 12;204:1114-5. doi: 10.1038/2041114b0.
5
Production of interferon by suspensions of human leucocytes.人白细胞悬液产生干扰素。
Proc Soc Exp Biol Med. 1961 Dec;108:799-803. doi: 10.3181/00379727-108-27072.
6
Immune specific induction of interferon production in cultures of human blood lymphocytes.人血淋巴细胞培养中干扰素产生的免疫特异性诱导。
Science. 1969 Jun 20;164(3886):1415-7. doi: 10.1126/science.164.3886.1415.
7
Antitumor effects of interferon preparations in mice.干扰素制剂对小鼠的抗肿瘤作用。
J Natl Cancer Inst. 1970 Aug;45(2):365-76.
8
9
Antitumour effect of lymphoid cells activated by interferon.干扰素激活的淋巴细胞的抗肿瘤作用。
Nature. 1970 Oct 3;228(5266):71-2. doi: 10.1038/228071a0.
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