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1
Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes.干扰素对致敏淋巴细胞特异性细胞毒性的增强作用。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5. doi: 10.1073/pnas.69.3.721.
2
Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells.干扰素对小鼠白血病L 1210细胞表面抗原表达的增强作用。
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2785-8. doi: 10.1073/pnas.70.10.2785.
3
[Intensification of cellular immune response by immunization of mice with the cells preincubated in interferon].[通过用在干扰素中预孵育的细胞对小鼠进行免疫来增强细胞免疫反应]
Biull Eksp Biol Med. 1976 Oct;82(10):1230-2.
4
[Effect of interferon on the immune response of mice to immunization with the cells of transplantable leukemias and sarkomas].[干扰素对小鼠针对可移植白血病和肉瘤细胞免疫接种的免疫反应的影响]
Vopr Onkol. 1977;23(9):44-50.
5
[Enhancement of the immune response following immunization with L1210 cells preliminarily incubated with interferon].用预先与干扰素孵育的L1210细胞免疫后免疫反应的增强
Biull Eksp Biol Med. 1976 Jun;81(6):706-7.
6
Interferon and spontaneous cytotoxicity in man. IV. Evidence for interferon as the factor in human interferon preparations causing enhancement of spontaneous cytotoxicity.人干扰素与自发细胞毒性。IV. 关于干扰素是人类干扰素制剂中导致自发细胞毒性增强的因素的证据。
J Clin Lab Immunol. 1980 Jan;3(1):35-8.
7
Interferon and cell division. I. Inhibition of the multiplication of mouse leukemia L 1210 cells in vitro by interferon preparations.干扰素与细胞分裂。一、干扰素制剂对小鼠白血病L 1210细胞体外增殖的抑制作用。
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1052-8. doi: 10.1073/pnas.66.4.1052.
8
Properties of interferon induced by purified protein derivative of tuberculin in mice sensitized with BCG or cell-wall skeleton of BCG.卡介苗或卡介苗细胞壁骨架致敏小鼠中结核菌素纯蛋白衍生物诱导的干扰素特性。
Gan. 1979 Aug;70(4):421-8.
9
Electrophoretically pure mouse interferon exerts multiple biologic effects.经电泳纯的小鼠干扰素具有多种生物学效应。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5308-12. doi: 10.1073/pnas.76.10.5308.
10
Protective effect of interferon on target cells exposed to cellular cytotoxicity.干扰素对暴露于细胞毒性的靶细胞的保护作用。
Immunology. 1980 Aug;40(4):637-43.

引用本文的文献

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Oncolytic virus treatment differentially affects the CD56 and CD56 NK cell subsets in vivo and regulates a spectrum of human NK cell activity.溶瘤病毒治疗在体内对CD56及CD56 NK细胞亚群有不同影响，并调节一系列人类NK细胞活性。
Immunology. 2022 May;166(1):104-120. doi: 10.1111/imm.13453. Epub 2022 Mar 9.
2
Role of interferons in cell differentiation and development.干扰素在细胞分化和发育中的作用。
Cytotechnology. 1991 Feb;5(Suppl 1):152-7. doi: 10.1007/BF00736836.
3
The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon α-2b therapy against advanced hepatocellular carcinoma.癌症干细胞标志物 CD133 是 S1+聚乙二醇干扰素 α-2b 治疗晚期肝细胞癌疗效的预测因子。
J Gastroenterol. 2011 Feb;46(2):212-21. doi: 10.1007/s00535-010-0294-5. Epub 2010 Aug 4.
4
Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression.皮下注射α干扰素与动脉内注射5-氟尿嘧啶联合治疗伴主要门静脉血栓形成的肝细胞癌；1型干扰素受体表达的作用
Br J Cancer. 2005 Sep 5;93(5):557-64. doi: 10.1038/sj.bjc.6602742.
5
Dermatomyositis after interferon alpha treatment.α干扰素治疗后发生的皮肌炎。
Med Oncol. 2000 Feb;17(1):64-9. doi: 10.1007/BF02826219.
6
Increased LAK and T cell activation in responding renal cell carcinoma patients after low dose cyclophosphamide, IL-2 and alpha-IFN.低剂量环磷酰胺、白细胞介素-2和α-干扰素治疗后，反应性肾细胞癌患者的淋巴因子激活的杀伤细胞（LAK）和T细胞活化增强。
Med Oncol. 1995 Jun;12(2):69-77. doi: 10.1007/BF01676706.
7
The treatment of multiple myeloma--an important MRC trial.多发性骨髓瘤的治疗——一项重要的医学研究委员会试验。
Br J Cancer. 1994 Nov;70(5):781-5. doi: 10.1038/bjc.1994.399.
8
Modulation of polyclonal B cell differentiation by human leucocyte alpha interferon.人白细胞α干扰素对多克隆B细胞分化的调节作用
Clin Exp Immunol. 1982 Sep;49(3):677-83.
9
The failure of human leukocyte interferon to influence the growth of human glioma cell populations: in vitro and in vivo studies.人白细胞干扰素对人胶质瘤细胞群体生长的影响：体外和体内研究
Br J Cancer. 1983 Dec;48(6):819-25. doi: 10.1038/bjc.1983.272.
10
Induction of human gamma interferon by structurally defined polypeptide fragments of group A streptococcal M protein.A组链球菌M蛋白的结构明确的多肽片段诱导人γ干扰素的产生。
Infect Immun. 1984 Jan;43(1):122-6. doi: 10.1128/iai.43.1.122-126.1984.

本文引用的文献

1
Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.悬浮L细胞中病毒干扰的定量研究。III. 干扰病毒和干扰素对细胞生长速率的影响。
Virology. 1962 Jun;17:324-34. doi: 10.1016/0042-6822(62)90123-x.
2
INTERFERON.干扰素
Adv Virus Res. 1963;10:1-38.
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THE ROLE OF THE RETICULOENDOTHELIAL SYSTEM IN INTERFERON FORMATION IN THE RABBIT.网状内皮系统在兔体内干扰素形成中的作用
Virology. 1965 Jan;25:163-6. doi: 10.1016/0042-6822(65)90268-0.
4
A RICH SOURCE OF MOUSE INTERFERON.小鼠干扰素的丰富来源。
Nature. 1964 Dec 12;204:1114-5. doi: 10.1038/2041114b0.
5
Production of interferon by suspensions of human leucocytes.人白细胞悬液产生干扰素。
Proc Soc Exp Biol Med. 1961 Dec;108:799-803. doi: 10.3181/00379727-108-27072.
6
Immune specific induction of interferon production in cultures of human blood lymphocytes.人血淋巴细胞培养中干扰素产生的免疫特异性诱导。
Science. 1969 Jun 20;164(3886):1415-7. doi: 10.1126/science.164.3886.1415.
7
Antitumor effects of interferon preparations in mice.干扰素制剂对小鼠的抗肿瘤作用。
J Natl Cancer Inst. 1970 Aug;45(2):365-76.
8
Interferon and cell division. II. Influence of various experimental conditions on the inhibition of L1210 cell multiplication in vitro by interferon preparations.干扰素与细胞分裂。II. 各种实验条件对干扰素制剂体外抑制L1210细胞增殖的影响。
J Natl Cancer Inst. 1970 Dec;45(6):1145-53.
9
Antitumour effect of lymphoid cells activated by interferon.干扰素激活的淋巴细胞的抗肿瘤作用。
Nature. 1970 Oct 3;228(5266):71-2. doi: 10.1038/228071a0.
10
Studies of allograft immunity in mice. II. Mechanism of target cell inactivation in vitro by sensitized lymphocytes.小鼠同种异体移植免疫研究。II. 致敏淋巴细胞在体外使靶细胞失活的机制。
Immunology. 1970 Apr;18(4):517-35.

干扰素对致敏淋巴细胞特异性细胞毒性的增强作用。

Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes.

作者信息

Lindahl P, Leary P, Gresser I

出版信息

Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5. doi: 10.1073/pnas.69.3.721.

DOI:10.1073/pnas.69.3.721
PMID:4501586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC426543/
Abstract

Mouse interferon preparations enhanced the specific cytotoxicity of sensitized lymphocytes for allogeneic target tumor cells. The factor responsible for the enhancement of cytotoxicity could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Thus, in addition to its well-known antiviral activity, and its effect on cell division, interferon also appears to enhance a specialized cellular function. It is suggested that a common mechanism of action underlies these seemingly different biologic phenomena, and that interferon may play a role in the regulation of fundamental cellular processes.

摘要

小鼠干扰素制剂增强了致敏淋巴细胞对同种异体靶肿瘤细胞的特异性细胞毒性。通过标准物理化学方法，无法将负责增强细胞毒性的因子与干扰素的抗病毒活性分离。因此，除了其众所周知的抗病毒活性及其对细胞分裂的影响外，干扰素似乎还能增强一种特殊的细胞功能。有人提出，这些看似不同的生物学现象背后存在一个共同的作用机制，并且干扰素可能在基本细胞过程的调节中发挥作用。