Lindahl P, Leary P, Gresser I
Proc Natl Acad Sci U S A. 1972 Mar;69(3):721-5. doi: 10.1073/pnas.69.3.721.
Mouse interferon preparations enhanced the specific cytotoxicity of sensitized lymphocytes for allogeneic target tumor cells. The factor responsible for the enhancement of cytotoxicity could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Thus, in addition to its well-known antiviral activity, and its effect on cell division, interferon also appears to enhance a specialized cellular function. It is suggested that a common mechanism of action underlies these seemingly different biologic phenomena, and that interferon may play a role in the regulation of fundamental cellular processes.
小鼠干扰素制剂增强了致敏淋巴细胞对同种异体靶肿瘤细胞的特异性细胞毒性。通过标准物理化学方法,无法将负责增强细胞毒性的因子与干扰素的抗病毒活性分离。因此,除了其众所周知的抗病毒活性及其对细胞分裂的影响外,干扰素似乎还能增强一种特殊的细胞功能。有人提出,这些看似不同的生物学现象背后存在一个共同的作用机制,并且干扰素可能在基本细胞过程的调节中发挥作用。