Haugen H, Akesson I, Enger E, Meberg A
Scand J Clin Lab Invest. 1978 Feb;38(1):49-51. doi: 10.3109/00365517809108402.
Uromucoid was determined in urine from persons or various ages with normal kidney function by a radial immunodiffusion technique. Uromucoid concentration was inversely correlated to diuresis. Excretion rates showed a weak correlation to body surface area in young adults of both sexes. Children had a greater excretion of uromucoid per m2 than young adults, and even newborn had a considerable excretion. Elderly subjects had similar excretion rates to young adults. Excretion rates were uninfluenced by sex, salt load or diuresis, and no difference between day and night excretion rates was observed. Intraindividual fluctuations were small, and determination of uromucoid in one single night's urine therefore gives an adequate expression of the uromucoid excretion rate.
采用放射免疫扩散技术测定了不同年龄肾功能正常者尿液中的尿类粘蛋白。尿类粘蛋白浓度与利尿呈负相关。排泄率与两性青年成人的体表面积呈弱相关。儿童每平方米尿类粘蛋白的排泄量比青年成人多，甚至新生儿也有相当量的排泄。老年受试者的排泄率与青年成人相似。排泄率不受性别、盐负荷或利尿的影响，昼夜排泄率之间未观察到差异。个体内波动较小，因此测定一晚尿液中的尿类粘蛋白就能充分反映尿类粘蛋白的排泄率。
