苯丙胺对脑儿茶酚胺周转率和运动活动的影响。
Effects of amphetamine on the turnover rate of brain catecholamines and motor activity.
作者信息
Costa E, Groppetti A, Naimzada M K
出版信息
Br J Pharmacol. 1972 Apr;44(4):742-51. doi: 10.1111/j.1476-5381.1972.tb07312.x.
Abstract
- Rats receiving (+)-amphetamine (either 0.3 or 0.2 mg/kg, i.v.) are anorexic. Only the former dose increases their motor activity. Both doses fail to change dopamine (DM) and noradrenaline (NA) concentrations in striatum and teldiencephalon. The turnover rate of striatal DM is increased only by 0.3 mg/kg of (+)-amphetamine; neither dose changes NA turnover rate in teldiencephalon.2. (-)-Amphetamine (1 mg/kg, i.v.) causes anorexia and hyperthermia in rats but it changes neither the steady-state concentration nor the turnover rate of striatal DM and tel-diencephalic NA. Motor activity is not increased by this dose of (-)-amphetamine.3. Cocaine (3 mg/kg, i.v.) increases motor activity and accelerates the turnover rate of striatal DM. This drug neither accelerates turnover rate of teldiencephalic NA nor causes anorexia.4. These observations suggest that the acceleration of striatal DM turnover rate elicited by (+)-amphetamine and cocaine may be associated with an effect on motor activity. In contrast, the increase of motor activity seems unrelated to the effects of these drugs on noradrenergic tracts of the teldiencephalon.
摘要
静脉注射0.3毫克/千克或0.2毫克/千克的（+）-苯丙胺的大鼠会出现厌食症状。只有前一个剂量会增加它们的运动活性。两种剂量均未能改变纹状体和端脑内多巴胺（DM）和去甲肾上腺素（NA）的浓度。只有0.3毫克/千克的（+）-苯丙胺会使纹状体DM的转换率增加；两种剂量均未改变端脑内NA的转换率。
静脉注射1毫克/千克的（-）-苯丙胺会导致大鼠厌食和体温过高，但它既不改变纹状体DM和端脑NA的稳态浓度，也不改变其转换率。这个剂量的（-）-苯丙胺不会增加运动活性。
静脉注射3毫克/千克的可卡因会增加运动活性，并加速纹状体DM的转换率。这种药物既不加速端脑NA的转换率，也不会导致厌食。
这些观察结果表明，（+）-苯丙胺和可卡因引起的纹状体DM转换率加速可能与对运动活性的影响有关。相比之下，运动活性的增加似乎与这些药物对端脑去甲肾上腺素能神经束的影响无关。
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