Simpson R T, Künzler P
Nucleic Acids Res. 1979 Apr;6(4):1387-415. doi: 10.1093/nar/6.4.1387.
Chicken erythrocyte inner histones (H2A, H2B, H3 and H4) were associated with the two complementary homopolymeric polydeoxyribonucleotides and the two alternating copolymeric polydeoxyribonucleotides. No evidence for formation of chromatin-like structures was obtained for the complexes with poly(dG) . poly(dC) or poly(dA) . poly(dT). Both poly (dGdC) . poly(dGdC) and poly(dAdT) . poly(dAdT) could be folded by histones to yield material digested by DNAase I to multiples of about 10 and by staphylococcal nuclease to 146 bp core particles. Due to the lack of sequence heterogeniety in the complex of histones with poly(dAdT) . poly(dAdT), core particles with remarkable fine structural detail are obtained. The internal organization of DNA in the AT-containing and GC-containing core particles appears not to be identical.
鸡红细胞内部组蛋白（H2A、H2B、H3和H4）与两种互补的同聚多脱氧核糖核苷酸以及两种交替共聚多脱氧核糖核苷酸相关联。对于与聚（dG）·聚（dC）或聚（dA）·聚（dT）形成的复合物，未获得形成染色质样结构的证据。聚（dGdC）·聚（dGdC）和聚（dAdT）·聚（dAdT）都可以被组蛋白折叠，产生被DNA酶I消化成约10的倍数的物质，并被葡萄球菌核酸酶消化成146bp的核心颗粒。由于组蛋白与聚（dAdT）·聚（dAdT）的复合物中缺乏序列异质性，因此获得了具有显著精细结构细节的核心颗粒。含AT和含GC的核心颗粒中DNA的内部组织似乎并不相同。
