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1
31P NMR studies of the solution structure and dynamics of nucleosomes and DNA.核小体与DNA溶液结构和动力学的31P核磁共振研究。
Nucleic Acids Res. 1979 Apr;6(4):1607-16. doi: 10.1093/nar/6.4.1607.
2
Conformation of DNA in chromatin protein-DNA complexes studied by infrared spectroscopy.通过红外光谱研究染色质蛋白 - DNA 复合物中 DNA 的构象。
Nucleic Acids Res. 1979 Apr;6(4):1479-93. doi: 10.1093/nar/6.4.1479.
3
1H NMR investigation of the conformational states of DNA in nucleosome core particles.核磁共振氢谱对核小体核心颗粒中DNA构象状态的研究。
Nucleic Acids Res. 1979;6(6):2327-37. doi: 10.1093/nar/6.6.2327.
4
Structure of nucleosomes, chromatin, and RNA polymerase-promoter complex as revealed by DNA-protein cross-linking.通过DNA-蛋白质交联揭示的核小体、染色质和RNA聚合酶-启动子复合物的结构。
Cold Spring Harb Symp Quant Biol. 1983;47 Pt 1:503-10. doi: 10.1101/sqb.1983.047.01.060.
5
[Structure of chromosomal deoxyribonucleoproteins. IX. Heterogeneity of chromatin subunits in vitro and location of histone H1].[染色体脱氧核糖核蛋白的结构。IX。体外染色质亚基的异质性及组蛋白H1的定位]
Mol Biol (Mosk). 1977 Mar-Apr;11(2):294-302.
6
Core nucleosomes by digestion of reconstructed histone-DNA complexes.通过消化重组的组蛋白-DNA复合物获得核心核小体。
Nucleic Acids Res. 1979 Apr;6(4):1449-65. doi: 10.1093/nar/6.4.1449.
7
The structure of the chromatin core particle in solution.溶液中染色质核心颗粒的结构。
Nucleic Acids Res. 1977 Sep;4(9):3199-214. doi: 10.1093/nar/4.9.3199.
8
Changes in chromatin structure at the replication fork. II The DNPs containing nascent DNA and a transient chromatin modification detected by DNAase I.复制叉处染色质结构的变化。II. 含有新生DNA的DNP以及DNA酶I检测到的瞬时染色质修饰
Nucleic Acids Res. 1981 Aug 25;9(16):3991-4005. doi: 10.1093/nar/9.16.3991.
9
Singlet-singlet energy transfer studies of the internal organization of nucleosomes.核小体内在组织的单重态-单重态能量转移研究。
Biochemistry. 1980 Apr 29;19(9):1797-805. doi: 10.1021/bi00550a011.
10
Assembly of active chromatin.活性染色质的组装
Biochemistry. 1986 Apr 22;25(8):2055-60. doi: 10.1021/bi00356a033.

引用本文的文献

1
The effect of ethidium bromide on DNA internal motions.溴化乙锭对DNA内部运动的影响。
Biophys J. 1980 Oct;32(1):632-3. doi: 10.1016/S0006-3495(80)85000-4.
2
Conformation of 145 base pair length poly (dG-dC) . poly (dG-dC) in solution and in association with histones.溶液中及与组蛋白结合时145个碱基对长度的聚（dG-dC）。聚（dG-dC）的构象
Nucleic Acids Res. 1980 May 10;8(9):2093-103. doi: 10.1093/nar/8.9.2093.
3
13C NMR relaxation and conformational flexibility of the deoxyribose ring.脱氧核糖环的13C核磁共振弛豫与构象灵活性
Nucleic Acids Res. 1982 Oct 11;10(19):6067-83. doi: 10.1093/nar/10.19.6067.
4
DNA motions in the nucleosome core particle.核小体核心颗粒中的DNA运动。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5896-900. doi: 10.1073/pnas.79.19.5896.
5
Molecular motion of DNA as measured by triplet anisotropy decay.通过三重态各向异性衰减测量的DNA分子运动。
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3518-22. doi: 10.1073/pnas.79.11.3518.
6
Nature of the open state in long polynucleotide double helices: possibility of soliton excitations.长链多核苷酸双螺旋开放状态的本质：孤子激发的可能性。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7222-6. doi: 10.1073/pnas.77.12.7222.
7
Direct observation of the torsional dynamics of DNA and RNA by picosecond spectroscopy.通过皮秒光谱法直接观察DNA和RNA的扭转动力学。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5593-7. doi: 10.1073/pnas.77.10.5593.
8
Conformation of DNA in chromatin core particles containing poly(dAdT)-poly(dAdT) studied by 31 P NMR spectroscopy.通过31P核磁共振光谱研究含聚（dAdT）-聚（dAdT）的染色质核心颗粒中DNA的构象。
Nucleic Acids Res. 1979 Sep 25;7(2):481-92. doi: 10.1093/nar/7.2.481.
9
Internal motions in DNA.DNA中的内部运动。
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6341-5. doi: 10.1073/pnas.76.12.6341.

本文引用的文献

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The molecular structure of polyadenylic acid.聚腺苷酸的分子结构。
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2
Quantitative determination of mononucleotide conformations in solution using lanthanide ion shift and broadenine NMR probes.
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Quantitative determination of conformations of flexible molecules in solution using lanthanide ions as nuclear magnetic resonance probes: application to adenosine-5'-monophosphate.
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Proton and phosphorus magnetic relaxation studies on the dynamic structure of single-stranded polyriboadenylic acid.
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Conformational study of cyclic and acyclic phosphate esters. CNDO/2 calculations of angle strain and torsional strain.环状和非环状磷酸酯的构象研究。角应变和扭转应变的CNDO/2计算。
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Proton and phosphorus NMR studies of d-CpG(pCpG)n duplexes in solution. Helix-coil transition and complex formation with actinomycin-D.溶液中d-CpG(pCpG)n双链体的质子和磷核磁共振研究。螺旋-卷曲转变以及与放线菌素-D的复合物形成。
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Conformational properties of adenylyl-3' leads to 5'-adenosine in aqueous solution.水溶液中腺苷-3′至5′-腺苷的构象性质。
Biochemistry. 1976 Feb 24;15(4):756-68. doi: 10.1021/bi00649a006.
8
Kinky helix.卷曲螺旋
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Nuclear magnetic resonance studies of the helix-coil transition of poly (dA-dT) in aqueous solution.水溶液中聚（dA-dT）螺旋-线圈转变的核磁共振研究。
Proc Natl Acad Sci U S A. 1976 Mar;73(3):674-8. doi: 10.1073/pnas.73.3.674.
10
Phosphorus-31 Fourier transform nuclear magnetic resonance study of mononucleotides and dinucleotides. 2. Coupling constants.单核苷酸和二核苷酸的磷-31傅里叶变换核磁共振研究。2. 耦合常数。
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核小体与DNA溶液结构和动力学的31P核磁共振研究。

31P NMR studies of the solution structure and dynamics of nucleosomes and DNA.

作者信息

Klevan L, Armitage I M, Crothers D M

出版信息

Nucleic Acids Res. 1979 Apr;6(4):1607-16. doi: 10.1093/nar/6.4.1607.

DOI:10.1093/nar/6.4.1607
PMID:450708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327794/
Abstract

31P NMR studies of 140 base pair DNA fragments in nucleosomes and free in solution show no detectable change in the internucleotide 31P chemical shift or linewidth when DNA is packaged into nucleosomes. Measurements of 31P spin-lattice relaxation times T1 and 31P-[H] nuclear Overhauser enhancements revealed internal motion with a correlation time of about 4 x 10(-10) sec in double helical DNA, both free in solution and bound to nucleosomal core proteins. This result implies greater dynamic mobility in double helical DNA than has previously been supposed.

摘要

对核小体中140个碱基对的DNA片段以及溶液中游离的该片段进行的31P核磁共振研究表明，当DNA包装成核小体时，核苷酸间31P化学位移或线宽没有可检测到的变化。对31P自旋-晶格弛豫时间T1和31P-[H]核Overhauser增强效应的测量显示，无论是溶液中游离的还是与核小体核心蛋白结合的双螺旋DNA，都存在相关时间约为4×10(-10)秒的内部运动。这一结果意味着双螺旋DNA中的动态流动性比之前认为的更大。