Pratt D M, Mole L E
Biochem J. 1975 Nov;151(2):337-49. doi: 10.1042/bj1510337.
The amino acid sequence has been completed for the constant region of the Fd fragments of heavy chains from rabbit IgG (immunoglobulin G) of allotype Aa1 and Aa3. The amino acid sequence given by Fruchter et al. [(1970) Biochem. J. 116, 249-259] for the constant region of the Fd fragment from Aa1 IgG was extended and in in part corrected to give a continuous sequence of 140 residues. No allotype-related sequence variation was found in the constant section of the Fd fragment. This evidence confirms the view that the differences in sequence between the variable regions of Aa1 and Aa3 IgG [Mole et al., (1971) Biochem. J. 124, 301-318] are responsible for the allotypic specificities.
已完成兔IgG（免疫球蛋白G）异型Aa1和Aa3重链Fd片段恒定区的氨基酸序列测定。Fruchter等人[（1970年）《生物化学杂志》116卷，249 - 259页]给出的Aa1 IgG的Fd片段恒定区氨基酸序列得到了扩展，并在部分内容上进行了修正，得到了一个由140个残基组成的连续序列。在Fd片段的恒定区未发现与异型相关的序列变异。这一证据证实了Aa1和Aa3 IgG可变区序列差异[莫尔等人，（1971年）《生物化学杂志》124卷，301 - 318页]决定异型特异性的观点。
