Plotnick H B, Weigel W W
Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):515-24.
The tissue distribution and excretion of an oral dose of 20 mg/kg of 14C-styrene was studied in both male and female rats at various time intervals after administration. Peak tissue levels were attained at or before 4 hours post administration. The organ with the highest concentration of radioactivity per unit weight was the kidney, followed, in order of decreasing concentration, by the liver and the pancreas. The data suggest a relationship between tissue distribution and kidney and liver toxicity. The high levels also found in the pancreas may bear some relationship to the reported increase in glucose tolerance in workers exposed to styrene. The principal route of excretion was via the kidneys, with 90% of the dose appearing in the urine within 24 hours of administration. Less than 2% of the dose was recovered from the feces.
对雄性和雌性大鼠口服20mg/kg的14C-苯乙烯后，在给药后的不同时间间隔研究了其组织分布和排泄情况。给药后4小时或之前达到组织峰值水平。单位重量放射性浓度最高的器官是肾脏，其次是肝脏和胰腺，浓度依次降低。数据表明组织分布与肾脏和肝脏毒性之间存在关联。在胰腺中也发现的高浓度可能与报告的接触苯乙烯工人葡萄糖耐量增加有一定关系。排泄的主要途径是通过肾脏，给药后24小时内90%的剂量出现在尿液中。从粪便中回收的剂量不到2%。
