Tashjian A H, Weintraub B D, Barowsky N J, Rabson A S, Rosen S W
Proc Natl Acad Sci U S A. 1973 May;70(5):1419-22. doi: 10.1073/pnas.70.5.1419.
Three clones of ectopic hormone-producing cells from a single human neoplasm (bronchogenic carcinoma) show different rates of synthesis and secretion of chorionic gonadotropin and its alpha and beta subunits. For each clone, the amount of one or the other subunit always exceeded that of the complete hormone molecule. These findings may be analogous to unbalanced immunoglobulin chain synthesis in certain forms of myeloma.
来自单一人类肿瘤（支气管癌）的三个异位激素产生细胞克隆，显示出绒毛膜促性腺激素及其α和β亚基的合成和分泌速率不同。对于每个克隆，一种或另一种亚基的量总是超过完整激素分子的量。这些发现可能类似于某些形式骨髓瘤中不平衡的免疫球蛋白链合成。
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