小鼠2号染色体上主要淋巴细胞分化抗原簇的证据。
Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2.
作者信息
Meruelo D, Offer M, Rossomando A
出版信息
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7460-4. doi: 10.1073/pnas.79.23.7460.
Abstract
The region of chromosome 2 between H-13 and H-3 has been shown to contain loci coding for a variety of other alloantigens, including Ly-4 and the locus coding for beta 2-microglobulin. Herein we show that Ly-6 and Ly-11 are coded for by genes in a segment of chromosome 2 adjacent to the H-3-H-13 region and that this segment of chromosome also contains the tightly linked loci coding for antigens Ala-1, DAG, H9/25, H-30, Ly-8, and ThB. In addition, at least one locus (and probably more) affecting susceptibility to leukemia induction is found within this gene cluster.
摘要
已证明2号染色体上位于H - 13和H - 3之间的区域包含编码多种其他同种异体抗原的基因座，包括Ly - 4以及编码β2 - 微球蛋白的基因座。在此我们表明，Ly - 6和Ly - 11由2号染色体上与H - 3 - H - 13区域相邻的一段基因编码，并且该染色体片段还包含紧密连锁的编码抗原Ala - 1、DAG、H9/25、H - 30、Ly - 8和ThB的基因座。此外，在这个基因簇中发现了至少一个（可能更多）影响白血病诱导易感性的基因座。
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