Evrin P E, Ström T
Ann Rheum Dis. 1984 Apr;43(2):267-74. doi: 10.1136/ard.43.2.267.
Repeated determinations of beta 2-microglobulin (beta 2m) and beta 2-microglobulin binding activity (beta 2m ba) in serum were performed during a follow-up of 23 patients with SLE. beta 2m was determined by a radioimmunoassay. Individual mean values were raised in 65% of the patients. The mean value for all patients, 2.9 mg/l, was significantly higher than that of the controls. The beta 2m concentrations parallelled the clinical disease activity in several cases with different disease manifestations. The beta 2m ba was determined by precipitation of 125I-labelled beta 2m with polyethylene glycol. Increased beta 2m ba was found in 26% of the SLE patients with the 90th percentile in 40 healthy subjects being taken as the upper normal limit. There were, however, no significant differences between the mean values for beta 2m ba in the patients and the controls. Patients with systemic lupus erythematosus (SLE), suffering exacerbation of their disease, had a higher mean beta 2m ba than those with less active disease. Variations of the serum beta 2m ba occurred especially in patients with active disease but did not seem to reflect the clinical course. The beta 2m ba was recovered in the IgG peak when SLE serum was subjected to gel chromatography on Sephadex G-200.
在对23例系统性红斑狼疮（SLE）患者的随访过程中，对其血清中的β2-微球蛋白（β2m）和β2-微球蛋白结合活性（β2m ba）进行了反复测定。β2m采用放射免疫分析法测定。65%的患者个体平均值升高。所有患者的平均值为2.9mg/l，显著高于对照组。在几例具有不同疾病表现的患者中，β2m浓度与临床疾病活动度平行。β2m ba通过用聚乙二醇沉淀125I标记的β2m来测定。在26%的SLE患者中发现β2m ba升高，以40名健康受试者的第90百分位数作为正常上限。然而，患者和对照组的β2m ba平均值之间没有显著差异。患有疾病加重的系统性红斑狼疮（SLE）患者的平均β2m ba高于疾病活动度较低的患者。血清β2m ba的变化尤其发生在疾病活动的患者中，但似乎并未反映临床病程。当SLE血清在Sephadex G - 200上进行凝胶色谱分析时，β2m ba在IgG峰中被回收。
