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小鼠β2-微球蛋白的完整氨基酸序列：品系相关多态性的结构证据。

Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism.

作者信息

Gates F T, Coligan J E, Kindt T J

出版信息

Proc Natl Acad Sci U S A. 1981 Jan;78(1):554-8. doi: 10.1073/pnas.78.1.554.

DOI:10.1073/pnas.78.1.554
PMID:6165997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC319092/
Abstract

Primary structural analyses of beta 3-microglobulin isolated from the tumor cell lines EL4.BU (derived from a C57BL/6 mouse) and C14 (derived from a BALB/c mouse) have revealed the presence of an amino acid difference at position 85 of this molecule. beta 2-Microglobulin isolated from histocompatibility antigens of EL4.BU has alanine at this position, whereas that from C14 has aspartic acid. Determination of the sequence of these molecules has employed radiochemical methodology that was developed in studies of murine histocompatibility antigens. The sequence obtained in this study is: Ile - Gln - Lys - Thr - Pro - Gln - Ile - Gln - Val - Tyr - Ser - Arg - His - Pro - Pro - Glu - Asn - Gly - Lys - Pro - Asn - Ile - Leu - Asn - Cys - Tyr - Val - Thr - Gln - Phe - His - Pro - Pro - His - Ile - Glu - Ile - Gln - Met - Leu - Lys - Asn - Gly - Lys - Lys - Ile Pro - Lys - Val - Glu - Met - Ser - Asp - Met - Ser - Phe - Ser - Lys - Asp - Trp - Ser - Phe - Tyr - Ile - Leu - Ala - His - Thr - Glu - Phe - Thr - Pro - Thr - Glu - Thr - Asp - Thr - Tyr - Ala - Cys - Arg - Val - Lys - His - Ala/Asp - Ser - Met - Ala - Glu - Pro - Lys - Thr - Val - Tyr - Trp - Asp - Arg - Asp - Met. Comparison of the sequence of murine beta 2-microglobulin to the sequences reported for the homologues from man, rabbit, and guinea pig indicate identities of 68%, 66%, and 61%, respectively.

摘要

对从肿瘤细胞系EL4.BU（源自C57BL/6小鼠）和C14（源自BALB/c小鼠）中分离出的β3-微球蛋白进行的一级结构分析显示，该分子第85位存在氨基酸差异。从EL4.BU组织相容性抗原中分离出的β2-微球蛋白在该位置为丙氨酸，而从C14中分离出的在该位置为天冬氨酸。这些分子序列的测定采用了在小鼠组织相容性抗原研究中开发的放射化学方法。本研究获得的序列为：异亮氨酸-谷氨酰胺-赖氨酸-苏氨酸-脯氨酸-谷氨酰胺-异亮氨酸-谷氨酰胺-缬氨酸-酪氨酸-丝氨酸-精氨酸-组氨酸-脯氨酸-脯氨酸-谷氨酸-天冬酰胺-甘氨酸-赖氨酸-脯氨酸-天冬酰胺-异亮氨酸-亮氨酸-天冬酰胺-半胱氨酸-酪氨酸-缬氨酸-苏氨酸-谷氨酰胺-苯丙氨酸-组氨酸-脯氨酸-脯氨酸-组氨酸-异亮氨酸-谷氨酸-异亮氨酸-谷氨酰胺-甲硫氨酸-亮氨酸-赖氨酸-天冬酰胺-甘氨酸-赖氨酸-赖氨酸-异亮氨酸-脯氨酸-赖氨酸-缬氨酸-谷氨酸-甲硫氨酸-丝氨酸-天冬氨酸-甲硫氨酸-丝氨酸-苯丙氨酸-丝氨酸-赖氨酸-天冬氨酸-色氨酸-丝氨酸-苯丙氨酸-酪氨酸-异亮氨酸-亮氨酸-丙氨酸-组氨酸-苏氨酸-谷氨酸-苯丙氨酸-苏氨酸-脯氨酸-苏氨酸-谷氨酸-苏氨酸-天冬氨酸-苏氨酸-酪氨酸-丙氨酸-半胱氨酸-精氨酸-缬氨酸-赖氨酸-组氨酸-丙氨酸/天冬氨酸-丝氨酸-甲硫氨酸-丙氨酸-谷氨酸-脯氨酸-赖氨酸-苏氨酸-缬氨酸-酪氨酸-色氨酸-天冬氨酸-精氨酸-天冬氨酸-甲硫氨酸。小鼠β2-微球蛋白序列与人、兔和豚鼠同源物报道序列的比较表明，同源性分别为68%、66%和61%。

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本文引用的文献

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Structural studies on H-2Db and H-2Kd molecules indicate that murine major histocompatibility b and d haplotype alloantigens share structural features.对H-2Db和H-2Kd分子的结构研究表明，小鼠主要组织相容性b和d单倍型同种异体抗原具有共同的结构特征。
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Nature. 1974 Jun 28;249(460):833-4. doi: 10.1038/249833a0.
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