准连锁平衡与双基因座系统的进化
Quasilinkage equilibrium and the evolution of two-locus systems.
作者信息
Nagylaki T
出版信息
Proc Natl Acad Sci U S A. 1974 Feb;71(2):526-30. doi: 10.1073/pnas.71.2.526.
In terms of intrinsic variables of the system, short, intermediate, transitional, and long (or asymptotic) times are defined for the evolution of a two-locus model with linkage and epistasis. It is argued that, during the first two and last periods, all quantities of genetic interest, such as the gametic frequencies, the mean fitness, the linkage disequilibrium, and the linkage disequilibrium ratio, Z, change with time in essentially the same manner, characteristic of the particular epoch concerned and determined in this paper, and therefore, when quasilinkage equilibrium occurs, it is a transitional phenomenon. Both continuous random births and deaths and discrete, nonoverlapping generations are considered.
就该系统的内在变量而言，对于具有连锁和上位性的双基因座模型的演化，定义了短、中、过渡和长（或渐近）时间。有人认为，在前两个时期和最后一个时期，所有具有遗传意义的量，如配子频率、平均适合度、连锁不平衡和连锁不平衡比率Z，随时间变化的方式基本相同，这是相关特定时期的特征，并在本文中确定，因此，当准连锁平衡出现时，它是一种过渡现象。同时考虑了连续随机出生和死亡以及离散、不重叠世代的情况。
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